Table 3 Top ten genes in module 5 that are most associated with a combined score for association with activated microglia and cognitive decline.

From: A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies

Gene

Microglia expression

Bulk expression

P value activated microglia

P value cognitive decline

Combined score

NBEAL2

6.1

9.2

3.90E-06

0.00015

8.72

ARRDC2

61.5

25.5

0.021

1.90E-08

8.06

DDX39A

99.4

28.7

0.027

3.10E-07

7.43

CC2D1B

15.4

20

3.60E-05

0.0029

7.32

VASP

23.6

12.2

0.0029

2.60E-05

7.3

S100A6

14.5

283

0.042

2.60E-07

7.28

LZTS2

16.2

34.4

0.0018

0.00011

7.09

MAP3K3

22.1

25.2

0.0038

5.90E-05

7.02

TRABD

78

13.1

0.0059

3.70E-05

6.98

TBC1D1

33.3

78.7

0.00085

0.00046

6.97

  1. Linear regression analysis was used to associate gene expression to activated microglia for 105 ROSMAP subjects and cognitive decline for the genes in module 5 for all 540 ROSMAP subjects. All the associations were adjusted for age, sex, study (ROS or MAP), RIN, and postmortem interval (PMI). Reported are the average expression in microglia and bulk tissue (FPKM), P value of the associations and the score that was used to combine the P values and rank the genes.
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