Fig. 4: Functional network in sex-specific genes. | Translational Psychiatry

Fig. 4: Functional network in sex-specific genes.

From: Genetic evidence of gender difference in autism spectrum disorder supports the female-protective effect

Fig. 4

Based on co-expression data from BrainSpan, 103 candidate genes formed a large interconnected functional network, mainly involving the following major functional blocks: cell–cell communication, chromosome organization, nervous system development, regulation of cellular process, and regulation of developmental process, distinguished by different fill colors of the nodes. The sex-specific genes are marked by different border colors of nodes. Different line types between nodes represent the interactions existing in female-brain samples or male-brain samples or in both female and male-brain samples. The top right image shows the distribution of co-expressed genes (genes with |R| > 0.80) among sex-specific genes in female and male-brain samples. p-values were calculated by the pairwise Wilcoxon test.

Back to article page