Fig. 2: TDT analysis Manhattan and Q-Q plot. | Translational Psychiatry

Fig. 2: TDT analysis Manhattan and Q-Q plot.

From: Novel genetic susceptibility loci identified by family based whole exome sequencing in Han Chinese schizophrenia patients

Fig. 2

a We performed a transmission disequilibrium test (TDT) for 65 schizophrenia families. The blue line means P-value is 1 × 10−4. The most significant SNP is rs1051823, which was located in replication initiator 1 (REPIN1) gene downstream region (OR: 2.86; CI 95%: 1.59–5.16; P-value = 1.495 × 10−5). b This figure shows the expected distribution of P-values plotted against the observed distribution of combined asymptotic test P-value (because of the heterogeneity brought by the 14 SCZ families with affected parents and the impact of parental illness states on transmission disequilibrium) for our transmission disequilibrium test. Our study did not show any signs of global inflation of test statistics with 1.002.

Back to article page