Table 3 Overview of the analysis to determine whether any of the 368 genes with rare and potentially functional variants have been implicated in previous next-generation sequencing studies (NGS) or genome-wide association studies (GWAS) of bipolar disorder (BD).

Gene	Family	Chr	Position	Ref	Alt	Mut Prot	MAF	Category	Publications
ANK3	0215	10	61815451	G	A	p.H1828Y	2.22E-05	BD NGS, BD GWAS	Chen et al., 2013; Fiorentino et al., 2014; Georgi et al., 2014; Mühleisen et al., 2014; Stahl et al., 2019
ANKRD39	0085	2	97520089	C	G	p.G64R	1.11E-05	BD GWAS	Stahl et al., 2019
BZRAP1	0062	17	56389544	G	A	p.R880W	3.51E-05	BD NGS	Kataoka et al., 2016
CABIN1	0109	22	24468401	A	G	p.E858G	1.10E-04	BD NGS	Goes et al., 2016
CUX1	0023	7	101877499	A	G	p.M1201V	NA	BD NGS	Goes et al., 2016
DPP3	0041	11	66249825	A	G	p.T52A	NA	BD GWAS	Stahl et al., 2019
MACF1	0014	1	39893177	C	T	p.T3394I	4.30E-04	BD NGS	Kataoka et al., 2016
MAU2	0085	19	19454736	C	T	p.T355M	2.24E-05	BD GWAS	Stahl et al., 2019
MYH7B	0215	20	33583320	T	C	p.I1003T	4.47E-05	BD GWAS	Green et al., 2013b
MYO10	0074	5	16670681	A	G	p.L1946S	5.62E-05	BD NGS	Kataoka et al., 2016
NISCH	0023	3	52526224	G	A	p.R1414Q	4.50E-05	BD GWAS	Stahl et al., 2019
OBSCN	0012	1	228481095	G	A	p.A3637T	1.11E-05	BD NGS	Goes et al., 2016
POC1A	1044	3	52183400	C	A	p.G94V	NA	BD GWAS	Stahl et al., 2019
PRKCZ	1044	1	2075740	G	A	p.R171H	4.41E-04	BD NGS	Goes et al., 2016
PROC	0074	2	128186037	G	T	p.A301S	NA	BD NGS	Kataoka et al., 2016
RIMS1	0215	6	73108704	AAGAAGAAG	AAGAAG	p.K717del	NA	BD GWAS	Stahl et al., 2019
SYNE1	0014	6	152683306	T	G	p.K3433T	NA	BD GWAS	Green et al., 2013a
TTBK2	0085	15	43044464	C	A	p.D994Y	5.55E-05	BD GWAS	Stahl et al., 2019
ZBTB24	0215	6	109802434	C	T	p.D266N	3.31E-05	BD NGS	Goes et al., 2016

Chr chromosome, Position chromosomal position according to hg19/GRCh37, Ref reference allele, Alt alternative allele, Mut Prot alteration on the protein level, MAF minor allele frequency, NA not available.

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