Fig. 2: Effects of TGF-β1 inhibitors (RepSox and SB431542) and neutralizing TGF-β1 antibody on antidepressant effects of (R)-ketamine in CSDS model. | Translational Psychiatry

Fig. 2: Effects of TGF-β1 inhibitors (RepSox and SB431542) and neutralizing TGF-β1 antibody on antidepressant effects of (R)-ketamine in CSDS model.

From: Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1

Fig. 2

a Locomotion (1 h, one-way ANOVA, F4,35 = 0.146, P = 0.964). b TST (3 h, one-way ANOVA, F4,35  = 5.439, P = 0.002). c FST (1 day, one-way ANOVA, F4,35 = 2.919, P = 0.035). d SPT (2 days, one-way ANOVA, F4,35 = 7.011, P < 0.001). Data are shown as mean ± SEM. (n = 8). *P < 0.05, **P < 0.01. e Locomotion (1 h, one-way ANOVA, F4,35 = 0.299, P = 0.877). f TST (3 h, one-way ANOVA, F4,35 = 16.586, P < 0.001). g FST (1 day, one-way ANOVA, F4,35 = 4.686, P = 0.004). h SPT (2 day, one-way ANOVA, F4,35 = 6.161, P = 0.001). i Locomotion (1 h, one-way ANOVA, F4,25 = 0.020, P = 0.999). j TST (3 h, one-way ANOVA, F4,35  = 8.165, P < 0.001). k FST (1 day, one-way ANOVA, F4,35 = 4.012, P = 0.015). l SPT (2 day, one-way ANOVA, F4,35 = 3.872, P = 0.021). Data are shown as mean ± SEM. (n = 8). *P < 0.05, **P < 0.01. ANOVA analysis of variance, CA control antibody, FST forced swimming test, NA neutralizing antibody, N.S. not significant, R-KT (R)-ketamine, SB SB431542, SPT sucrose preference test, TST tail suspension test.

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