Table 3 Comparisons among the RBANS total and five domain scores by diagnostic and genotypic groups.

From: Neuregulin 3 rs10748842 polymorphism contributes to the effect of body mass index on cognitive impairment in patients with schizophrenia

RBANS scores

Patients with schizophreniaa

Controls

Diagnosis

Genotype

Diagnosis X genotype

TT

(N = 544)

TC + CC

(N = 81)

TT

(N = 347)

TC + CC

(N = 53)

F

p

F

p

F

p

Immediate memory

56.28 ± 15.10

54.24 ± 15.65

76.02 ± 17.07

74.06 ± 20.33

167.34

<0.001

1.71

0.19

0.001

0.98

Attention

61.83 ± 17.70a

57.70 ± 13.08a

87.87 ± 20.26

84.47 ± 21.43

226.60

<0.001

4.60

0.03b

0.04

0.87

Language

73.42 ± 17.54

70.54 ± 16.70

94.15 ± 12.98

92.85 ± 13.96

203.97

<0.001

1.92

0.17

0.28

0.60

Visuospatial/construction

75.02 ± 17.50

71.70 ± 15.94

80.08 ± 15.89

78.06 ± 13.73

13.09

<0.001

2.88

0.09

0.18

0.68

Delayed memory

61.99 ± 18.37

61.96 ± 18.09

86.54 ± 14. 93

85.06 ± 17.48

213.15

0.001

0.21

0.64

0.20

0.66

Total score

59.12 ± 13.38

56.64 ± 11.35

80.41 ± 15.02

78.30 ± 16.70

261.71

<0.001

2.98

0.08

0.02

0.89

BMI

23.97 ± 4.52

23.99 ± 4.00

25.10 ± 4.20

25.50 ± 4.64

10.00

0.002

0.25

0.62

0.20

0.66

  1. aA significant genotypic effect on Attention score in patients with schizophrenia.
  2. bThere was a significant genotype effect on Attention score in all subjects (F = 4.60, p = 0.03). Patients carrying TC + CC had lower attention score than those carrying CC in patient group (adjusted F = 4.77, p = 0.029). There was no difference in attention score between controls carrying TC + CC and carrying CC (adjusted F = 0.20, p = 0.66).
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