Fig. 2: Effects of OXTR genetic risk on connectivity of the NAcc in females with and without ASD.
From: Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity
a Brain regions showing greater connectivity with the NAcc as a function of increased OXTR genetic risk are shown in red/yellow. Areas showing reduced functional connectivity with the NAcc as a function of increased OXTR genetic risk are shown in blue/cyan. b In females with ASD, greater NAcc-Subcortical connectivity is associated with higher scores on the restricted and repetitive behaviors (RRB) scale of the Autism Diagnostic Observation Scale (ADOS-2)47. c Areas in which diagnostic group differences were observed in the relationship between OXTR risk-allele dosage and NAcc functional connectivity. Graphs are for illustrative purposes and show the relationship between NAcc connectivity and number of OXTR risk alleles for each participant. Maps are shown at z > 3.1, corrected for multiple comparisons at p < 0.05. NT neurotypical; ASD autism spectrum disorder.
