Table 2 Summary of the results obtained after meta-analyses.

 CC

391

2632

438

2674

0.96 [0.73, 1.27]

Tau² = 0.12; Chi² = 25.00, df = 10 (P = 0.005); I² = 60%

Z = 0.27 (P = 0.79)

 TDT

172

849

171

849

1.01 [0.79, 1.28]

Tau² = 0.00; Chi² = 3.96, df = 5 (P = 0.56); I² = 0%

Z = 0.04 (P = 0.96)

 CC

288

3366

550

6094

1.07 [0.85, 1.33]

Tau² = 0.07; Chi² = 23.08, df = 14 (P = 0.06); I² = 39%

Z = 0.56 (P = 0.57)

 TDT

220

1890

248

1889

0.87 [0.71, 1.06]

Tau² = 0.00; Chi² = 10.64, df = 11 (P = 0.47); I² = 0%

Z = 1.40 (P = 0.16)

 CC

55

616

33

620

1.95 [0.37, 10.29]

Tau² = 2.72; Chi² = 25.05, df = 4 (P < 0.0001); I² = 84%

Z = 0.79 (P = 0.43)

 TDT

7

66

6

64

1.15 [0.36, 3.62]

Not applicable

Z = 0.23 (P = 0.82)

 CC

96

1254

514

6522

1.15 [0.73, 1.80]

Tau² = 0.10; Chi² = 5.83, df = 3 (P = 0.12); I² = 49%

Z = 0.61 (P = 0.54)

 CC

4

56

2

56

2.08 [0.36, 11.83]

Not applicable

Z = 0.82 (P = 0.41)

 CC

2087

2632

2094

2674

1.00 [0.83, 1.21]

Tau² = 0.03; Chi² = 15.60, df = 10 (P = 0.11); I² = 36%

Z = 0.04 (P = 0.97)

 TDT

686

950

599

950

1.85 [0.94, 3.63]

Tau² = 0.73; Chi² = 58.64, df = 6 (P < 0.00001); I² = 90%

Z = 1.78 (P = 0.07)

 CC

2143

3366

4196

6094

0.79 [0.69, 0.91]

Tau² = 0.03; Chi² = 26.67, df = 14 (P = 0.02); I² = 48%

Z = 3.31 (P = 0.0009)

 TDT

1020

1890

1054

1889

0.89 [0.73, 1.10]

Tau² = 0.07; Chi² = 24.33, df = 11 (P = 0.01); I² = 55%

Z = 1.08 (P = 0.28)

 CC

428

684

406

720

1.14 [0.49, 2.66]

Tau² = 0.86; Chi² = 39.51, df = 5 (P < 0.00001); I² = 87%

Z = 0.31 (P = 0.76)

 TDT

32

66

27

64

1.29 [0.65, 2.58]

Not applicable

Z = 0.72 (P = 0.47)

 CC

848

1426

4148

6636

0.82 [0.65, 1.04]

Tau² = 0.04; Chi² = 9.91, df = 5 (P = 0.08); I² = 50%

Z = 1.66 (P = 0.10)

 TDT

41

56

41

56

1.00 [0.43, 2.31]

Not applicable

Z = 0.00 (P = 1.00)

 CC

13

1789

18

2176

0.84 [0.39, 1.80]

Tau² = 0.00; Chi² = 4.90, df = 8 (P = 0.77); I² = 0%

Z = 0.46 (P = 0.65)

 TDT

5

265

4

265

1.27 [0.33, 4.87]

Tau² = 0.00; Chi² = 1.02, df = 2 (P = 0.60); I² = 0%

Z = 0.35 (P = 0.72)

 CC

2020

7618

4279

16506

1.25 [1.07, 1.45]

Tau² = 0.11; Chi² = 104.24, df = 26 (P < 0.00001); I² = 75%

Z = 2.77 (P = 0.006)

 TDT

916

3202

720

3201

1.40 [1.23, 1.59]

Tau² = 0.01; Chi² = 23.89, df = 20 (P = 0.25); I² = 16%

Z = 5.09 (P < 0.00001)

 CC

92

986

124

820

0.61 [0.45, 0.83]

Tau² = 0.00; Chi² = 4.38, df = 5 (P = 0.50); I² = 0%

Z = 3.13 (P = 0.002)

 TDT

35

164

28

162

1.34 [0.54, 3.31]

Tau² = 0.26; Chi² = 2.54, df = 1 (P = 0.11); I² = 61%

Z = 0.63 (P = 0.53)

 CC

393

1490

1321

6696

1.25 [0.95, 1.65]

Tau² = 0.07; Chi² = 14.05, df = 6 (P = 0.03); I² = 57%

Z = 1.59 (P = 0.11)

 TDT

59

313

58

313

1.02 [0.68, 1.53]

Tau² = 0.00; Chi² = 0.86, df = 2 (P = 0.65); I² = 0%

Z = 0.10 (P = 0.92)

 CC

72

2952

61

2914

1.22 [0.83, 1.78]

Tau² = 0.01; Chi² = 11.15, df = 11 (P = 0.43); I² = 1%

Z = 1.01 (P = 0.31)

 TDT

32

679

20

679

1.49 [0.65, 3.44]

Tau² = 0.32; Chi² = 6.17, df = 4 (P = 0.19); I² = 35%

Z = 0.94 (P = 0.35)

 CC

848

3560

1072

6311

1.41 [1.19, 1.67]

Tau² = 0.06; Chi² = 32.56, df = 15 (P = 0.005); I² = 54%

Z = 4.04 (P < 0.0001)

 TDT

531

1869

448

1864

1.28 [1.05, 1.56]

Tau² = 0.04; Chi² = 17.36, df = 11 (P = 0.10); I² = 37%

Z = 2.49 (P = 0.01)

 CC

133

976

515

2588

0.62 [0.41, 0.93]

Tau² = 0.13; Chi² = 11.37, df = 5 (P = 0.04); I² = 56%

Z = 2.32 (P = 0.02)

 TDT

64

181

90

179

0.63 [0.19, 2.06]

Tau² = 0.62; Chi² = 6.58, df = 1 (P = 0.01); I² = 85%

Z = 0.76 (P = 0.45)

 CC

295

1157

1267

5864

1.13 [0.90, 1.43]

Tau² = 0.02; Chi² = 4.82, df = 3 (P = 0.19); I² = 38%

Z = 1.05 (P = 0.29)

 TDT

11

56

9

56

1.28 [0.48, 3.37]

Not applicable

Z = 0.49 (P = 0.62)