Fig. 1: Polygenic risk scores for bipolar disorder and schizophrenia in multiplex families and the general population. | Translational Psychiatry

Fig. 1: Polygenic risk scores for bipolar disorder and schizophrenia in multiplex families and the general population.

From: Contribution of common and rare damaging variants in familial forms of bipolar disorder and phenotypic outcome

Fig. 1

Violin plot showing polygenic risk scores for bipolar disorder (BD-PRS) (a) and schizophrenia (SZ-PRS) (b) calculated for affected (gray) and unaffected (blank) individuals. Scores were normalized on the control median value and compared between controls (N = 1636), non-familial forms of bipolar disorder (BDnonfam, N = 218), familial forms of bipolar disorder (BDfam, N = 144), affected subjects in multiplex families (FAMaff, N = 21), and unaffected subjects in multiplex families (FAMunaff, N = 16) with Wilcoxon test. A p value threshold of 0.3319 including 27,100 independent SNPs was chosen for BD-PRS as the best threshold to discriminate between individuals with bipolar disorder (BD) and controls. A p value threshold of 0.2025 including 21,668 independent SNPs was chosen for SZ-PRS as the best threshold to discriminate BD and controls. Nominal p values are indicated for each comparison. Significant results after Bonferroni correction for multiple testing are indicated with stars: *padj < 0.05, **padj < 0.01, ***padj < 0.001, ****padj < 0.0001.

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