Fig. 3: Correlation between the polygenic risk score and the number of rare damaging mutations in multiplex families with bipolar disorder. | Translational Psychiatry

Fig. 3: Correlation between the polygenic risk score and the number of rare damaging mutations in multiplex families with bipolar disorder.

From: Contribution of common and rare damaging variants in familial forms of bipolar disorder and phenotypic outcome

Fig. 3

Each dot represents a single individual and lines symbolize results of the linear regression. The polygenic risk score (PRSsum) results from the sum of the scores of BDonly-PRS, SZonly-PRS, and the BD–SZ-PRS for each individual. a No correlation was observed between the polygenic risk score and the number of rare damaging mutations in affected individuals (R2 = −0.014, F = 0.76, p = 0.40, padj = 0.80). b Unaffected individuals showed a significant negative linear regression (R2 = 0.32, F = 7.19, p = 0.02, padj = 0.04) between the polygenic risk score and the number of rare damaging mutations.

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