Table 1 Multivariate analyses in family and non-familial forms of bipolar disorder using polygenic risk scores based on bipolar disorder-specific-, schizophrenia-specific-, and bipolar disorder and schizophrenia shared-associated variants.

From: Contribution of common and rare damaging variants in familial forms of bipolar disorder and phenotypic outcome

 

β

s.e.

za

p

padjb

BDfam vs. controls

     

 BDonly-PRS

2477.5

1097.9

1.64

0.02

0.07

 SZonly-PRS

2892.4

931.6

2.26

0.002

0.006

 BD-SZ-PRS

3624.7

739.5

4.90

9.5E-07

2.9E-06

BDnonfam vs. controls

 BDonly-PRS

3022.6

934.6

3.23

0.001

0.004

SZonly-PRS

44.7

767.0

0.06

0.95

1

 BD-SZ-PRS

3162.6

598.6

5.28

1.3E-07

3.8E-07

BDfam vs. BDnonfam

BDonly-PRS

−270.2

1362.8

−0.20

0.84

1

 SZonly-PRS

3229.7

1204.4

2.68

0.007

0.02

BD-SZ-PRS

384.6

847.0

0.45

0.65

1

  1. BD bipolar disorder, BDfam familial forms of BD, BDnonfam non-familial forms of BD, PRS polygenic risk score, p nominal p value, s.e. standard error, SZ schizophrenia.
  2. aWald test.
  3. bAdjusted p value after Bonferroni correction for multiple testing. Significant results (padj < 0.05) are indicated in bold.
Back to article page