Fig. 2: Diagrams of structural equation models (SEM). | Translational Psychiatry

Fig. 2: Diagrams of structural equation models (SEM).

From: Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank

Fig. 2

a Multiple indicators, multiple causes (MIMIC) model52 for neurostructural properties of each network. A separate model was applied to FA, grey matter thickness (CT), and grey matter volume (GMV). From each individual bilateral node (L: left; R: right) or pathway, a latent score was calculated for FA, CT, GMV controlling for sex and whole-brain structural properties at the manifest level (i.e., whole brain FA/CT/GMV). Relation between FA/CT/GMV and PRSSZ is indicated by path β; path γ represents the association between the interaction of age and PRSSZ and FA/CT/GM factors; path δ represents the association between age and the latent factor. PRSSZ was corrected for sex and population stratification (paths not shown). The dashed line represents a possible residual correlation between nodes. b Path diagram of mediation model, where the ε coefficient represents the regression of X on M, λ coefficient the regression of M on Y, and σ coefficient the direct path of X on Y. The product of the ε and λ coefficients describes the indirect path of X on Y through M (σ′).

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