Fig. 2: Neuroinflammation in schizophrenia-relevant regions of amphetamine-sensitized mice. | Translational Psychiatry

Fig. 2: Neuroinflammation in schizophrenia-relevant regions of amphetamine-sensitized mice.

From: Human umbilical cord-derived mesenchymal stem cells alleviate schizophrenia-relevant behaviors in amphetamine-sensitized mice by inhibiting neuroinflammation

Fig. 2

a An immunohisotochemical study was performed in order to determine morphology and number of Iba-1 positive cells in medial prefrontal cortex (mPFC), ventral region of striatum (vSt), Nucleus accumbens (Nacc) and dentate gyrus (DG) of hippocampus. b To quantify, we counted Iba-1 positive cells in vST, Nacc, mPFC, and DG. Microglia-related factors, which are functional phenotype markers (P2RY12, CD86, iNOS, CX3CR1, CD200R, and TREM2) and cytokines (TNF-α, IL-1β, KMO, TGF-β, and IFG-1), were examined in the hippocampus (c) and the striatum (d) using qPCR. n = 3 in each group in immunohistochemistry. For qPCR, n = 8–10 per group and the data shown as mean ± standard error of the mean (SEM), *p < 0.05, ***p < 0.001 compared with CON. Scale bar is 10 μm.

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