Table 2 Results from SNP_level regression analyses on OCD dimensions.

From: Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study

SNP

N Cases (MAF)

N Controls (MAF)

OR (CI)

P

CHR

Position (BP)

A1/A2

Gene

Upstream gene

Downstream gene

Aggressive dimension

rs11127905

277 (0.28)

97 (0.14)

2.55 (2.01–3.25)

9.89 × 10−05

chr3

85710336

[T/C]

CADM2

  

rs1202392

278 (0.13)

97 (0.25)

0.42 (0.34–0.52)

7.91 × 10−05

chr7

148914740

[A/G]

ZNF282

  

rs13064299

278 (0.43)

97 (0.63)

0.45 (0.37–0.54)

8.66 × 10−06

chr3

187865100

[T/C]

 

RP11-430L16.1 (292)

LPP-AS2 (3894)

rs13180857

278 (0.37)

97 (0.54)

0.45 (0.37–0.54)

2.31 × 10−05

chr5

124754302

[T/C]

 

RP11-395P13.6 (22629)

RP11-756H20.1 (74652)

rs16918167

278 (0.27)

97 (0.43)

0.49 (0.41–0.59)

7.96 × 10−05

chr9

101815339

[T/G]

COL15A1

  

rs2189993

278 (0.54)

97 (0.38)

2.13 (1.76–2.57)

7.10 × 10−05

chr7

82193853

[A/G]

 

CACNA2D1 (120739)

MTHFD2P5 (25311)

rs3799867

278 (0.14)

97 (0.27)

0.42 (0.33–0.52)

5.62 × 10−05

chr6

46594121

[A/G]

CYP39A1

  

rs41307

278 (0.45)

97 (0.62)

0.47 (0.39–0.57)

4.95 × 10−05

chr7

28674854

[T/C]

CRX10B5

  

rs6819000

278 (0.34)

97 (0.50)

0.48 (0.40–0.57)

6.46 × 10−05

chr4

65574910

[T/G]

 

RP11-63H19.6 (97304)

RP11-158O16.1 (57938)

rs9463221

278 (0.14)

97 (0.27)

0.42 (0.34–0.52)

7.22 × 10−05

chr6

46588027

[T/G]

CYP39A1

  

Contamination dimension

rs10466538

172 (0.18)

203 (0.08)

2.71 (2.13–3.46)

3.95 × 10−05

chr11

125169468

[T/G]

PKNOX2

  

rs10882846

172 (0.15)

203 (0.26)

0.45 (0.37–0.55)

9.18 × 10−05

chr10

82984432

[T/C]

 

AL356154.1 (79945)

NRG3 (650638)

rs11016302

172 (0.20)

203 (0.09)

2.35 (1.89–2.92)

8.99 × 10−05

chr10

130320996

[A/C]

 

RP11–264X1018.1 (202518)

RP11-442O18.2 (390147)

rs11158195

172 (0.41)

203 (0.55)

0.54 (0.46–0.63)

8.80 × 10−05

chr14

58507598

[A/G]

C14orf37

  

rs11210992

171 (0.37)

203 (0.52)

0.54 (0.46–0.63)

6.74 × 10−05

chr1

44878549

[T/C]

RNF220

  

rs12832515

172 (0.32)

203 (0.19)

2.19 (1.82–2.63)

2.15 × 10−05

chr12

128219762

[A/G]

 

RP11-526P6.1 (98750)

RP11-749H20.1 (58310)

rs1557627

170 (0.32)

203 (0.18)

2.34 (1.94–2.83)

6.96 × 10−06

chr22

19677207

[T/C]

 

AC000067.1 (22129)

sx10p-05 (24780)

rs16935065

172 (0.22)

203 (0.11)

2.32 (1.88–2.86)

5.96 × 10−05

chr8

69699756

[A/G]

C8orf34

  

rs2492501

172 (0.28)

203 (0.16)

2.10 (1.75–2.52)

4.98 × 10−05

chr1

112931256

[T/G]

 

snoU13 (17527)

CTTNBP2NL (7547)

rs515077

172 (0.44)

203 (0.29)

2.07 (1.76–2.44)

9.00;× 10−06

chr6

8180286

[A/G]

 

EEF1E1 (77475)

RP11–203H2.1 (149602)

rs6477714

172 (0.30)

203 (0.45)

0.51 (0.44–0.60)

3.04 × 10−05

chr9

112367400

[T/G]

 

YBX1P6 (70788)

PALM2 (35668)

rs7671165

172 (0.20)

203 (0.33)

0.46 (0.39–0.56)

3.39 × 10−05

chr4

6401102

[T/C]

PPP2R2C

  

rs78287729

172 (0.10)

203 (0.03)

4.35 (3.04–6.24)

4.53 × 10−05

chr4

145192851

[T/G]

 

GYPA (130947)

RP11-361D14.2 (234201)

rs7925725

172 (0.33)

203 (0.48)

0.51 (0.43–0.60)

4.24 × 10−05

chr11

131449365

[A/C]

NTM

  

rs7968104

172 (0.31)

203 (0.18)

2.16 (1.80–2.60)

2.97 × 10−05

chr12

128222410

[A/G]

 

RP11-526P6.1 (101398)

RP11-749H20.1 (55662)

rs8123755

172 (0.07)

203 (0.17)

0.34 (0.26–0.44)

4.63 × 10−05

chr20

23682133

[A/G]

 

CST4 (12456)

CST2P1 (9824)

rs930134

172 (0.57)

203 (0.42)

1.95 (1.67–2.29)

2.41 × 10−05

chr18

71568010

[A/G]

 

RN7SL401P (155546)

RP11-25L3.3 (13630)

rs9546461

172 (0.57)

203 (0.42)

1.85 (1.58–2.16)

8.42 × 10−05

chr13

84212815

[T/C]

 

RNU6-67P (340513)

SLITRK1 (238529)

rs985035

172 (0.57)

203 (0.41)

1.93 (1.65–2.25)

2.37 × 10−05

chr13

84262897

[A/G]

 

RNU6-67P (390595)

SLITRK1 (188447)

Order dimension

rs1039038

172 (0.46)

203 (0.51)

0.48 (0.41–0.57)

5.54 × 10−06

chr11

40511611

[A/C]

LRRC4C

  

rs10771752

172 (0.49)

202 (0.47)

2.21 (1.87–2.61)

1.83 × 10−06

chr12

30802885

[A/C]

IPO8

  

rs10979978

172 (0.25)

203 (0.34)

0.49 (0.41–0.59)

7.79 × 10−05

chr9

112406744

[T/C]

PALM2

  

rs12146709

172 (0.23)

203 (0.20)

2.50 (2.05–3.05)

3.70 × 10−06

chr12

30888001

[T/C]

CAPRIN2

  

rs12294573

172 (0.35)

203 (0.36)

1.97 (1.67–2.33)

4.75 × 10−05

chr11

24087714

[T/C]

 

RNU6-783P (216286)

RP11-2F20.1 (169309)

rs14139

172 (0.50)

203 (0.47)

2.22 (1.88–2.63)

1.50 × 10−06

chr12

30782598

[T/C]

IPO8

  

rs1601548

172 (0.39)

203 (0.38)

0.50 (0.42–0.59)

6.30 × 10−05

chr2

108735612

[T/C]

 

AC023672.1 (19664)

AC019100.3 (48592)

rs16888991

172 (0.29)

203 (0.30)

2.02 (1.70–2.40)

4.35 × 10−05

chr5

21168358

[T/C]

 

RP11-774D14.1 (230558)

RP11-811J10.1 (28471)

rs1811248

172 (0.33)

203 (0.38)

0.52 (0.44–0.61)

8.40 × 10−05

chr7

28421036

[T/G]

CRX10B5

  

rs2249654

172 (0.19)

203 (0.18)

0.36 (0.29–0.46)

8.04 × 10−06

chr5

53892279

[A/G]

 

SNX18 (49864)

AC112198.1 (211759)

rs2724693

172 (0.29)

203 (0.27)

2.02 (1.71–2.39)

2.47 × 10−05

chr3

137807259

[A/G]

DZIP1L

  

rs2724693

172 (0.29)

203 (0.27)

2.02 (1.71–2.39)

2.47 × 10−05

chr3

137807259

[A/G]

DZIP1L

  

rs2724697

172 (0.29)

203 (0.27)

1.98 (1.68–2.34)

3.82 × 10−05

chr3

137798155

[T/C]

DZIP1L

  

rs2993531

172 (0.41)

203 (0.44)

1.95 (1.65–2.30)

5.20 × 10−05

chr1

212190116

[A/C]

INTS7

  

rs2993531

172 (0.41)

203 (0.44)

1.95 (1.65–2.30)

5.20 × 10−05

chr1

212190116

[A/C]

INTS7

  

rs34473884

172 (0.17)

203 (0.20)

0.40 (0.32–0.50)

6.15 × 10−05

chr10

133761285

[A/G]

PPP2R2D

  

rs442800

172 (0.29)

203 (0.26)

1.98 (1.67–2.34)

5.53 × 10−05

chr3

137786442

[T/C]

DZIP1L

  

rs4963128

172 (0.33)

203 (0.26)

0.49 (0.41–0.59)

8.00 × 10−05

chr11

589564

[T/C]

PHRF1

  

rs6487927

172 (0.50)

203 (0.47)

2.21 (1.87–2.61)

1.58 × 10−06

chr12

30826335

[T/C]

IPO8

  

rs6487928

172 (0.23)

203 (0.20)

2.53 (2.07–3.08)

2.99 × 10−06

chr12

30828095

[A/G]

IPO8

  

rs7316477

172 (0.50)

203 (0.47)

2.22 (1.88–2.63)

1.50 × 10−06

chr12

30786098

[A/G]

IPO8

  

rs750523

172 (0.39)

203 (0.38)

0.49 (0.41–0.58)

3.40 × 10−05

chr2

108746221

[T/C]

 

AC023672.1 (30273)

AC019100.3 (37983)

rs756474

172 (0.23)

203 (0.32)

0.47 (0.39–0.57)

6.73 × 10−05

chr8

95634950

[A/G]

 

RP11-267M23.7 (28121)

RP11-22C11.2 (14563)

rs7937152

172 (0.41)

203 (0.39)

1.95 (1.65–2.29)

4.44 × 10−05

chr11

131936494

[T/C]

NTM

  

rs7944117

172 (0.39)

203 (0.41)

1.93 (1.65–2.26)

2.44 × 10−05

chr11

40591800

[T/C]

LRRC4C

  

rs832665

171 (0.47)

203 (0.46)

0.50 (0.43–0.59)

4.22 × 10−05

chr2

108731604

[T/C]

 

AC023672.1 (15656)

AC019100.3 (52600)

rs894943

172 (0.26)

203 (0.27)

0.49 (0.40–0.58)

8.80 × 10−05

chr17

74916307

[A/G]

MGAT5B

  

Hoarding dimension

rs1010156

91 (0.62)

284 (0.45)

2.22 (1.83–2.69)

3.19 × 10−05

chr8

23190941

[T/C]

LOXL2

  

rs10187022

91 (0.49)

284 (0.33)

2.13 (1.77–2.56)

4.71 × 10−05

chr2

34341570

[A/C]

AC009499.1

  

rs12670403

91 (0.58)

284 (0.41)

2.35 (1.92–2.88)

2.37 × 10−05

chr7

17309279

[A/C]

 

AC098592.8 (236177)

AC003075.4 (10179)

rs13068223

91 (0.35)

284 (0.52)

0.44 (0.36–0.53)

2.13 × 10−05

chr3

156470955

[A/G]

LINC00886

  

rs1469064

91 (0.49)

284 (0.32)

2.39 (1.97–2.92)

9.95 × 10−06

chr5

164859465

[T/C]

CTC-535M15.2

  

rs17137472

91 (0.58)

284 (0.41)

2.26 (1.85–2.76)

4.71 × 10−05

chr7

17296072

[T/C]

 

AC098592.8 (222970)

AC003075.4 (23386)

rs1807512

90 (0.46)

282 (0.31)

2.16 (1.78–2.63)

9.10 × 10−05

chr22

17221495

[T/C]

 

VWFP1 (36128)

AC005301.8 (6264)

rs1944828

91 (0.21)

284 (0.10)

2.92 (2.25–3.80)

4.53 × 10−05

chr11

127048359

[T/C]

 

CTD-2234N14.2 (38729)

CTD-2234N14.1 (12305)

rs285714

91 (0.40)

284 (0.26)

2.24 (1.84–2.73)

4.67 × 10−05

chr15

93126781

[T/C]

RP11–386M24.3

  

rs4143121

91 (0.45)

284 (0.31)

2.29 (1.88–2.80)

3.16 × 10−05

chr3

1764453

[T/C]

 

AC090043.1 (126524)

RPL23AP39 (7301)

rs7326856

91 (0.43)

283 (0.26)

2.12 (1.77–2.55)

4.16 × 10−05

chr13

66338922

[T/C]

 

STARP1 (453837)

HNRNPA3P5 (23142)

rs956818

91 (0.18)

284 (0.35)

0.37 (0.30–0.47)

1.41 × 10−05

chr16

6537353

[T/G]

RP11-420N3.2

  

rs956818

91 (0.18)

284 (0.35)

0.37 (0.30–0.47)

1.41 × 10−05

chr16

6537353

[T/G]

RBFOX1

  

rs9575590

91 (0.33)

284 (0.52)

0.42 (0.35–0.51)

4.47 × 10−06

chr13

85066303

[A/G]

 

UBE2D3P4 (471406)

MTND4P1 (27935)

Sexual/ religious dimension

rs10076327

95 (0.44)

280 (0.27)

2.41 (1.96–2.97)

2.12 × 10−05

chr5

122367347

[A/G]

PPIC

  

rs10408163

95 (0.41)

279 (0.26)

2.24 (1.83–2.73)

5.49 × 10−05

chr19

47597102

[T/C]

ZC3H4

  

rs10804925

95 (0.55)

280 (0.39)

2.11 (1.75–2.55)

7.39 × 10−05

chr3

190094024

[A/G]

CLDN16

  

rs10902225

95 (0.28)

280 (0.45)

0.47 (0.39–0.57)

9.14 × 10−05

chr11

835065

[T/C]

CD151

  

rs11128702

95 (0.33)

280 (0.20)

2.33 (1.89–2.88)

6.31 × 10−05

chr3

14530133

[T/C]

SLC6A6

  

rs11131820

95 (0.46)

280 (0.29)

2.16 (1.79–2.60)

3.48 × 10−05

chr4

178683325

[T/C]

LINC01098

  

rs12213157

95 (0.32)

280 (0.18)

2.31 (1.88–2.84)

5.22 × 10−05

chr6

163640489

[A/G]

PACRG

  

rs12552120

95 (0.36)

280 (0.51)

0.47 (0.38–0.57)

8.87 × 10−05

chr9

90514482

[T/C]

 

SPATA31E1 (10668)

SPATA31C1 (14926)

rs12929114

95 (0.55)

280 (0.37)

2.18 (1.80–2.63)

3.79 × 10−05

chr16

65532244

[T/C]

LINC00922

  

rs1441537

95 (0.11)

280 (0.24)

0.32 (0.25–0.42)

2.34 × 10−05

chr5

3261155

[T/C]

 

CTD-2029E14.1 (79809)

LINC01019 (156111)

rs144597

94 (0.46)

280 (0.29)

2.17 (1.79–2.64)

6.90 × 10−05

chr5

122223232

[A/C]

SNX24

  

rs1460040

95 (0.42)

280 (0.26)

2.30 (1.87–2.82)

5.59 × 10−05

chr5

122105232

[A/G]

 

RP11-166A12.1 (38852)

SNX2 (5459)

rs1606502

95 (0.58)

280 (0.44)

2.13 (1.76–2.58)

7.95 × 10−05

chr8

57529208

[T/C]

 

RP11-17A4.1 (27862)

RP11-17A4.4 (23252)

rs16871518

95 (0.14)

280 (0.29)

0.35 (0.28–0.45)

1.76 × 10−05

chr5

3254413

[T/C]

 

CTD-2029E14.1 (73067)

LINC01019 (162853)

rs17023204

95 (0.28)

280 (0.17)

2.43 (1.94–3.04)

7.53 × 10−05

chr4

148329646

[T/C]

 

MIR548G (63777)

RP11–364M6.1 (17480)

rs17635830

95 (0.09)

280 (0.24)

0.32 (0.24–0.42)

4.30 × 10−05

chr17

52847941

[T/C]

 

ARL2BPP8 (15931)

RN7SKP14 (369)

rs2303108

95 (0.39)

280 (0.25)

2.23 (1.82–2.73)

7.46 × 10−05

chr19

47589895

[T/C]

ZC3H4

  

rs2303108

95 (0.39)

280 (0.25)

2.23 (1.82–2.73)

7.46 × 10−05

chr19

47589895

[T/C]

ZC3H4

  

rs2345493

95 (0.14)

280 (0.29)

0.37 (0.29–0.47)

2.95 × 10−05

chr2

18292201

[T/G]

KCNS3

  

rs2826856

95 (0.29)

280 (0.15)

2.42 (1.96–2.99)

2.67 × 10−05

chr21

22842175

[A/G]

NCAM2

  

rs35521

95 (0.36)

280 (0.20)

2.33 (1.90–2.87)

4.29 × 10−05

chr5

107081478

[A/G]

 

RN7SL782P (10711)

RN7SKP122 (64852)

rs3844159

95 (0.26)

280 (0.13)

2.43 (1.94–3.04)

8.07 × 10−05

chr10

60733376

[T/C]

 

RN7SKP196 (104088)

LINC00844 (26010)

rs4685147

95 (0.62)

280 (0.44)

2.30 (1.90–2.78)

1.23 × 10−05

chr3

14424656

[T/C]

 

RP11–536I6.1 (30588)

RNA5SP124 (11492)

rs4853954

95 (0.49)

280 (0.32)

2.06 (1.72–2.47)

6.58 × 10−05

chr2

2935910

[T/C]

AC019118.2

  

rs62136856

95 (0.41)

280 (0.26)

2.26 (1.85–2.76)

4.17 × 10−05

chr19

47573527

[A/G]

ZC3H4

  

rs7470248

95 (0.36)

280 (0.51)

0.47 (0.38–0.57)

8.87 × 10−05

chr9

90515619

[A/G]

 

SPATA31E1 (11805)

SPATA31C1 (13789)

rs974728

95 (0.21)

278 (0.36)

0.41 (0.33–0.51)

4.59 × 10−05

chr12

11934852

[A/G]

X10TV6

  
  1. SNP single nucleotide polymorphism, MAF minor allele frequency, OR (CI), odds ratio (confidence interval); A1/A2 allele 1, allele 2, CHR. chromosome, BP base pairs.
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