Table 5 Results from enrichment analyses on Hoarding dimension.
From: Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study
Annotation Cluster 1 | Enrichment Score: 6.97 | ||||||
|---|---|---|---|---|---|---|---|
Category | Term | Count (%) | P-value | Genes | List total | Fold enrichment | FDR |
GOTERM_BP_DIRECT | GO:2001030~negative regulation of cellular glucuronidation | 8 (3.90) | 9.39 × 10−14 | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A4, UGT1A1 | 176 | 95.41 | 1.74 × 10−14 |
GOTERM_BP_DIRECT | GO:1904224~negative regulation of glucuronosyltransferase activity | 8 (3.90) | 9.39 × 10−14 | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A4, UGT1A1 | 176 | 95.41 | 1.47 × 10−12 |
GOTERM_BP_DIRECT | GO:0045922~negative regulation of fatty acid metabolic process | 8 (3.90) | 4.19 × 10−13 | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A4, UGT1A1 | 176 | 84.81 | 6.57 × 10−12 |
GOTERM_BP_DIRECT | GO:0052695~cellular glucuronidation | 8 (3.90) | 1.25 × 10−10 | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A4, UGT1A1 | 176 | 47.70 | 1.96 × 10−09 |
KEGG_PATHWAY | hsa00053:Ascorbate and aldarate metabolism | 9 (4.39) | 2.86 × 10−10 | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A5, UGT1A4, UGT1A1 | 77 | 29.78 | 3.33 × 10−09 |
REACTOME_PATHWAY | R-HSA-156588 (Glucuronidation) | 8 (3.90) | 5.67 × 10−10 | UGT1A7, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A5, UGT1A4, UGT1A1 | 104 | 38.78 | 7.06 × 10−09 |
KEGG_PATHWAY | hsa00040:Pentose and glucuronate interconversions | 9 (4.39) | 1.69 × 10−09 | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A5, UGT1A4, UGT1A1 | 77 | 24.36 | 1.97 × 10−08 |
KEGG_PATHWAY | hsa00140:Steroid hormone biosynthesis | 10 (4.88) | 1.04 × 10−08 | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A5, UGT1A4, UGT1A1, CYP19A1 | 77 | 15.40 | 1.21 × 10−07 |
KEGG_PATHWAY | hsa00860:Porphyrin and chlorophyll metabolism | 9 (4.39) | 1.33 × 10−08 | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A5, UGT1A4, UGT1A1 | 77 | 19.14 | 1.55 × 10−07 |
KEGG_PATHWAY | hsa00830:Retinol metabolism | 9 (4.39) | 4.11 × 10−07 | UGT1A7, UGT1A10, UGT1A6, UGT1A9, UGT1A8, UGT1A3, UGT1A5, UGT1A4, UGT1A1 | 77 | 12.56 | 4.78 × 10−06 |
GOTERM_BP_DIRECT | GO:0042573~retinoic acid metabolic process | 5 (2.44) | 1.05 × 10−05 | UGT1A7, UGT1A9, UGT1A8, UGT1A3, UGT1A1 | 176 | 34.07 | 1.65 × 10−4 |
GOTERM_BP_DIRECT | GO:0008152~metabolic process | 11 (5.37) | 1.06 × 10−05 | UGT1A7, UGT1A10, UGT1A6, ACSM1, UGT1A9, UGT1A8, UGT1A3, UGT1A5, UGT1A4, GALNS, UGT1A1 | 176 | 6.25 | 1.67 × 10−4 |
Annotation Cluster 2 | Enrichment Score: 2.96 | ||||||
|---|---|---|---|---|---|---|---|
Category | Term | Count | P-value | Genes | List total | Fold enrichment | FDR |
GOTERM_BP_DIRECT | GO:0019532~oxalate transport | 4 (1.95) | 1.73 × 10−04 | SLC26A6, SLC26A5, SLC26A10, SLC26A2 | 176 | 34.69 | 0.003 |
GOTERM_BP_DIRECT | GO:1902358~sulfate transmembrane transport | 4 (1.95) | 2.28 × 10−04 | SLC26A6, SLC26A5, SLC26A10, SLC26A2 | 176 | 31.80 | 0.004 |
GOTERM_BP_DIRECT | GO:0015701~bicarbonate transport | 5 (2.44) | 0.001 | SLC26A6, SLC26A5, CFTR, SLC26A10, SLC26A2 | 176 | 10.84 | 0.017 |
