Fig. 1: Longer-term treatment with fluoxetine accelerated bone loss in both rabbits with bilateral ovariectomy (OVX) and rats with OVX and chronic unpredictable mild stress (CUMS). | Translational Psychiatry

Fig. 1: Longer-term treatment with fluoxetine accelerated bone loss in both rabbits with bilateral ovariectomy (OVX) and rats with OVX and chronic unpredictable mild stress (CUMS).

From: Long-term use of fluoxetine accelerates bone loss through the disruption of sphingolipids metabolism in bone marrow adipose tissue

Fig. 1

a Long-term fluoxetine significantly accelerated the reduction of bone mineral density (BMD) in OVX rabbits. b The BMD of right distal right femora was significantly lower in long-term fluoxetine treated rats compared with the controls. c Six-weeks of fluoxetine treatment caused the dramatic reduction of the ratio for bone volume to total volume (BV/TV) in rats with OVX and CUMS. The trabecular bone region of the right distal femora was used for analysis. The dose of fluoxetine (Flx) was 10 mg/kg/d. Data were mean ± sem, N = 8 animals/group. **P < 0.01 and *P < 0.05 based on one-way ANOVA analysis followed by Tukey’s test.

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