Fig. 3: Network medicine framework.
From: Drug repositioning for psychiatric and neurological disorders through a network medicine approach
a WDD searches for gene–PND and drug–PND associations. All WDD results were filtered to keep only relationships supported by two documents or more and at least 50% confidence. b Selection of exclusive genes of each PND that are coexpressed in brain tissue according to Gandal et al.15. c WDD searches for drug–gene associations using exclusive coexpressed genes of PNDs. d Removal of drugs obtained in a and of drugs targeting more than one gene. e Drug prioritization through literature searches and selection of relevant cases.
