Fig. 3: Anterior insula stimulation reduces the intake of liquid rewards. | Translational Psychiatry

Fig. 3: Anterior insula stimulation reduces the intake of liquid rewards.

From: Anterior insula stimulation suppresses appetitive behavior while inducing forebrain activation in alcohol-preferring rats

Fig. 3

Effects of chemogenetic manipulation on alcohol (a), sucrose (b), and deprivation-induced water consumption (c), as well as locomotor activity (d). For alcohol, sucrose, and water drinking, the data are depicted as mean intake (±SEM) at the baseline (BL) and after CNO injections in groups expressing the EGFP control vector, the Gq-DREADDs, or the Gi-DREADDs. For alcohol drinking, data are derived from n = 9 EGFP-expressing, n = 11 Gq-DREADD-expressing, and n = 10 Gi-DREADD-expressing rats. For sucrose intake, data are from n = 10 EGFP-expressing, n = 10 Gq-DREADD-expressing, and n = 8 Gi-DREADD-expressing rats. For water intake, data represent n = 8 Gq-DREADD and n = 8 Gi-DREADD-expressing rats. Panel c depicts the effects of saline and CNO on locomotor activity (mean ambulatory counts ± SEM) in rats expressing Gq-DREADDs (n = 8) during a 30-min session. Asterisks indicate a significant difference of CNO-treated subjects from their baseline. **P < 0.01, ***P < 0.001, paired sample t-test.

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