Fig. 4: Brain activation induced by CNO (0.5 mg/kg i.v). | Translational Psychiatry

Fig. 4: Brain activation induced by CNO (0.5 mg/kg i.v).

From: Anterior insula stimulation suppresses appetitive behavior while inducing forebrain activation in alcohol-preferring rats

Fig. 4

Stimulation of Gq-DREADDs expressed in the anterior insula. a Time course of CNO-induced relative cerebral blood volume (rCBV) response (red line; n = 16) compared to the control group without DREADDs (blue line; n = 12). The dashed vertical line at t = 0 marks the time of CNO injection. b Anatomical localization of brain areas significantly activated by CNO in animals transfected with DREADDs versus controls (z > 1.9, P = 0.01). c Mean (±SEM) rCBV response in brain areas of interest after administration of CNO. ***P < 0.001, *P < 0.05, compared to the control group. AntIns anterior insular cortex, PosIns posterior insular cortex, OFC orbitofrontal cortex, Cg cingulate cortex, IL infralimbic cortex, PrL prelimbic cortex, AcbC nucleus accumbens core, AcbSh nucleus accumbens shell, VTA ventral tegmental area.

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