Fig. 2: True positive rate (TPR), true negative rate (TNR), false positive rate (FPR) and false negative rate (FNR) showed as percentage (%) of the values for the multi-domain of immune blood and cognitive biomarkers predictions for the bipolar disorder vs. control pair, for the Schizophrenia vs. control pair, and for the bipolar disorder vs. Schizophrenia pair.

a, b General performance maximizing both sensitivity and specificity. The predictions were categorized as “success” when the predictions of TPR and FNR were based on high sensitivity (i.e., 80% or more) and also as “success” when the predictions of TNR and FPR were based on high specificity (i.e., 80% or more). The predictions were categorized as “moderate success” when the predictions of the above were based on moderate sensitivity or specificity (i.e., from 70 to 79%), and the predictions were categorized as “fail” when these predictions were based in low or very low sensitivity or specificity (i.e., 69% or less). c, d High sensitivity (90%) scenario. The predictions were categorized as “success” when the FPR was below 30%, as a “moderate success” when those values were from 31 to 50%, and as “failure” when those values were higher than 50%. e, f High specificity (90%) scenario. The predictions were categorized as “success” when the FNR was below 30%, as “moderate success” when those values were from 31 to 50%, and as “failure” when those values were higher than 50%. Color code: “success” showed in green, “moderate success” showed in yellow, and “failure” showed in red.