Table 2 Biomarkers contributing to the multi-domain model composed of immune blood-based and cognitive biomarkers.

From: Precision psychiatry with immunological and cognitive biomarkers: a multi-domain prediction for the diagnosis of bipolar disorder or schizophrenia using machine learning

Model

BD vs. CT

SZ vs. CT

BD vs. SZ

Single-domain

IgG1

HSV2

IgG1

Immune blood biomarkers

IgG3

Toxoplasma gondii IgM

HSV2

 

Anti-cardiolipin

CMV

IgG4

 

IgG2

IgG2

Toxoplasma gondii IgM

 

Anti-TTGG

IgG

Anti-gliadin A

 

Anti-CCP

ANCA

Anti-TTGG

Single-domain

WAIS deterioration

WAIS DSC

WAIS DSC

Cognitive biomarkers

WAIS DSC

CVLT LDCR

CVLT LDCR

 

WAIS inform

CVLT SDCR

WAIS DS

 

NART33 IQ

WAIS deterioration

CVLT SDCR

 

WAIS Let-Num Seq

WAIS Let-Num Seq

NART33 IQ

 

CVLT LDCR

WAIS DS

WAIS BD

Multi-domain

WAIS deterioration

WAIS DSC

WAIS DSC

Immune blood and

WAIS DSC

CVLT LDCR

IgG1

cognitive biomarkers

IgG1

CVLT SDCR

WAIS DS

 

Toxoplasma gondii IgG

WAIS deterioration

WAIS Obj Ass

 

Anti-cardiolipin

WAIS arithmetic

CVLT LDCR

 

WAIS inform

WAIS Let-Num Seq

NART33 IQ

  1. WAIS DSC WAIS digit symbol coding total score, WAIS Inform WAIS information total score, CVLT SDCR CVLT total number of correct answers during list a short delay cued recall, CVLT LDCR CVLT total number of correct answers during list a long delay cued recall, WAIS DS WAIS digit spam total score, WAIS Obj Ass WAIS object assembly total score, NART33 IQ NART 33 items total IQ score, WAIS BD WAIS block design total score.
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