Table 2 The comparisons of cerebrospinal fluid neuroplasticity-associated protein levels between each psychiatric group and control group.

From: Cerebrospinal fluid neuroplasticity-associated protein levels in patients with psychiatric disorders: a multiplex immunoassay study

 

Schizophrenia (n = 94)

 

Bipolar disorder (n = 68)

 

Major depressive disorder (n = 104)

 

Control (n = 118)

 
 

Mean ± standard deviation

vs. control

Mean ± standard deviation

vs. control

Mean ± standard deviation

vs. control

Mean ± standard deviation

Statistical comparison

APP (ng/ml)

498.5 ± 206.5

p = 0.019 (0.11)

475.9 ± 221.1

p = 0.002 (0.011)

537.3 ± 256.7

p = 0.12

584.3 ± 266.0

F(3, 378) = 3.78, p = 0.011, partial η2 = 0.029

Contactin-1 (pg/ml)

4272.5 ± 486.1

p = 0.089

4270.9 ± 586.9

p = 0.060

4367.2 ± 569.4

p = 0.45

4419.1 ± 581.9

F(3, 378) = 1.60, p = 0.19, partial η2 = 0.013

ErbB3 (pg/ml)

2539.1 ± 648.4

p = 0.43

2545.0 ± 908.6

p = 0.10

2649.2 ± 764.9

p = 0.50

2682.9 ± 951.8

F(3, 378) = 0.89, p = 0.45, partial η2 = 0.007

GDNF (pg/ml)

6.3 ± 1.2

p = 0.035 (0.21)

6.5 ± 1.5

p = 0.27

6.7 ± 1.3

p = 0.63

6.7 ± 1.3

F(3, 378) = 1.65, p = 0.18, partial η2 = 0.013

HGF (pg/ml)

81.4 ± 18.5

p = 0.38

86.8 ± 21.1

p = 0.66

86.1 ± 20.7

p = 0.78

84.8 ± 21.2

F(3, 378) = 0.61, p = 0.61, partial η2 = 0.005

HGF receptor (pg/ml)

1105.8 ± 473.5

p = 0.33

1030.8 ± 547.3

p = 0.060

1197.5 ± 567.5

p = 0.86

1187.6 ± 590.8

F(3, 378) = 1.69, p = 0.17, partial η2 = 0.013

NCAM-1 (ng/ml)

172.4 ± 50.0

p = 0.25

165.0 ± 59.9

p = 0.017 (0.097)

178.4 ± 59.0

p = 0.39

184.0 ± 63.5

F(3, 378) = 1.95, p = 0.12, partial η2 = 0.015

Neuropilin-1 (pg/ml)

3075.4 ± 857.0

p = 0.57

2981.4 ± 1238.4

p = 0.15

3189.6 ± 1182.0

p = 0.96

3199.5 ± 1104.1

F(3, 378) = 0.82, p = 0.48, partial η2 = 0.006

S100B (pg/ml)

818.3 ± 227.8

p = 0.72

830.3 ± 287.4

p = 0.98

819.6 ± 324.4

p = 0.81

831.4 ± 290.1

F(3, 378) = 0.60, p = 0.98, partial η2 = 0.000

VEGF receptor 1 (pg/ml)

37.2 ± 12.7

p = 0.12

33.3 ± 15.2

p = 0.51

33.2 ± 15.0

p = 0.42

34.5 ± 15.1

F(3, 378) = 2.08, p = 0.10, partial η2 = 0.016

VEGF receptor 2 (pg/ml)

664.7 ± 212.7

p = 0.90

683.4 ± 287.3

p = 0.67

674.2 ± 268.8

p = 0.78

668.1 ± 223.2

F(3, 378) = 0.07, p = 0.98, partial η2 = 0.001

  1. APP amyloid precursor protein, GDNF glial cell line-derived neurotrophic factor, HGF hepatocyte growth factor, NCAM neural cell adhesion molecule, S100B S100 calcium-binding protein B, VEGF vascular endothelial growth factor.
  2. Significant p values are shown in bold cases (right parentheses indicate corrected p values).