Fig. 4: TRAP decreases lateral ventricle volume and increases GCL width in females. | Translational Psychiatry

Fig. 4: TRAP decreases lateral ventricle volume and increases GCL width in females.

From: Effects of early life exposure to traffic-related air pollution on brain development in juvenile Sprague-Dawley rats

Fig. 4

a Representative MR images of female brains at postnatal day 53-55. Arrows indicate location of lateral ventricles. b Lateral ventricular volumes and (c) whole brain volumes in TRAP vs. FA females and males. d Representative images of the GCL and SGZ from TRAP vs. FA females. Bar = 100 µm. e Quantification of immature neurons measured as percent area within the SGZ and CGL immunopositive for DCX. f Quantification of cycling immature neurons quantified as percentage of Ki67+/DCX+ cells. g Mature neuron numbers estimated as the GCL width based on NeuN immunoreactivity. h Correlation between lateral ventricular volume and GCL width in female rats (Spearman correlation coefficient; r = −0.6041, p = 0.0428; n = 11 animals). White = FA; gray = TRAP. *p < 0.05; **p < 0.01 (Student’s t test).

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