Fig. 2: Genetic risk for schizophrenia and clinical/demographic variables. | Translational Psychiatry

Fig. 2: Genetic risk for schizophrenia and clinical/demographic variables.

From: Genome sequencing broadens the range of contributing variants with clinical implications in schizophrenia

Fig. 2

This figure shows results for analyses of five clinical variables/features (family history of schizophrenia/psychosis, ID, early age at onset, mild syndromic features, and biological sex) with respect to rare clinically relevant variant burden, defined as the number of CNVs and/or SNVs/indels per individual. Orange and blue coloured boxes, and vertical bars representing 95% confidence intervals, indicate respectively results for individuals with and without each of the five variables; numbers for each subgroup are indicated in brackets under variable labels (Supplemental Table S5), and p-values for analyses are provided above graphed results. Clinically relevant rare variant burden was significantly greater for females, individuals with broadly defined ID, or with mild syndromic features.

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