Fig. 2: The results of logistic regression analysis.

Abbreviations: CN cognitively normal participants, SCD participants with subjective cognitive decline, CN− cognitively normal participants with negative CSF Aβ42 [A−], SCD+ participants with subjective cognitive decline and positive CSF Aβ42 [A+], BIN1 bridging integrator 1 gene promoter; BIN1_01–06 six different regions of bridging integrator 1 gene promoter, OR odds ratio, CI confidence interval. Logistic regression models were used to test the associations between methylation levels of BIN1 promoter and preclinical AD susceptibility, adjusting for age, gender, education, and APOE ɛ4 status.