Fig. 4: Associations between methylation levels of BIN1 promoter and CSF AD biomarkers in different APOE ε4 status. | Translational Psychiatry

Fig. 4: Associations between methylation levels of BIN1 promoter and CSF AD biomarkers in different APOE ε4 status.

From: Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer’s disease

Fig. 4

Abbreviations: CSF cerebrospinal fluid, Aβ amyloid-β, p-tau phosphorylated tau protein, t-tau total tau protein, APOE apolipoprotein E gene, LCI low value of 95% confidence interval, UCI up value of 95% confidence interval, BIN1 bridging integrator 1 gene promoter, BIN1_01 the 01 region of bridging integrator 1 gene promoter. A Associations between methylation levels of BIN1 promoter and CSF AD biomarkers in different APOE ε4 status. B Associations between methylation levels of BIN1_01 region on BIN1 promoter and CSF AD biomarkers in different APOE ε4 status. Multiple linear regression models were used to examine the associations between methylation levels of BIN1 promoter and CSF biomarkers, adjusting for age, gender, and education.

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