Table 1 Characteristics of participants from CABLE database.

From: Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer’s disease

Variable

CN

SCD

Total

p

N

484

330

814

–

Age (year) mean (SD)

60.01 (10.47)

64.08 (9.88)

61.47 (10.06)

<0.0001#

Gender (Female/Male)

185/299

146/184

331/483

0.1002£

Education (year) mean (SD)

9.96 (4.43)

9.84 (4.38)

9.91 (4.41)

0.7892#

APOE ε4 carriers N (+/−, +/+)

67 (66, 1)

55 (50, 5)

122 (116, 6)

0.3134£

CM-MMSE mean (SD)

27.85 (2.36)

27.78 (2.21)

27.82 (2.29)

0.2533#

CSF Aβ42 (pg/mL) mean (SD)

195.79 (128.60)

168.19 (94.06)

184.60 (116.58)

0.0004#

CSF p-tau (pg/mL) mean (SD)

37.02 (9.74)

38.44 (11.12)

37.59 (10.34)

0.1727#

CSF t-tau (pg/mL) mean (SD)

172.40 (79.36)

187.34 (103.06)

178.46 (89.96)

0.0710#

CSF p-tau/Aβ42 mean (SD)

0.23 (0.10)

0.27 (0.12)

0.25 (0.11)

<0.0001#

CSF t-tau/Aβ42 mean (SD)

1.06 (0.63)

1.31 (0.92)

1.16 (0.77)

<0.0001#

  1. CN cognitively normal participants, SCD participants with subjective cognitive decline, APOE apolipoprotein E gene, CSF cerebrospinal fluid, Aβ amyloid-β, p-tau phosphorylated tau protein, t-tau total tau protein, CM-MMSE China-Modified Mini-Mental State Examination, SD standard deviation.
  2. Bold indicated that the results were statistically significant.
  3. #Intergroup comparisons were tested by Mann–Whitney U test.
  4. £Intergroup comparisons were tested by Chisquare test.
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