Table 4 Associations between methylation levels of BIN1 promoter and CSF biomarkers after adjusting SNPs.

Variable	Total		CN		SCD
Variable	β	p	β	p	β	p
BIN1
CSF Aβ42	28.9148	0.0001	15.3313	0.1312	45.5261	<0.0001
CSF p-tau	−13.2467	0.0708	1.9133	0.8457	−29.2024	0.0103
CSF t-tau	−11.5700	0.1090	4.4243	0.6501	−27.7005	0.0143
CSF p-tau/Aβ42	−36.2108	<0.0001	−15.9422	0.1145	−59.0300	<0.0001
CSF t-tau/Aβ42	−34.9525	<0.0001	−11.6603	0.2461	−58.1587	<0.0001
BIN1_01
CSF Aβ42	3.2062	0.0001	1.7765	0.1099	4.9218	0.0001
CSF p-tau	−1.5151	0.0600	0.2198	0.8382	−3.4143	0.0062
CSF t-tau	−1.2881	0.1050	0.5215	0.6250	−3.1605	0.0107
CSF p-tau/Aβ42	−4.0228	<0.0001	−1.8270	0.0983	−6.5380	<0.0001
CSF t-tau/Aβ42	−3.8733	<0.0001	−1.3162	0.2314	−6.4468	<0.0001

Bold indicated that the results were statistically significant.
Multiple linear regression models were used to test the associations between methylation levels of BIN1 promoter and CSF biomarkers, adjusting for age, gender, education, APOE ɛ4 status and two SNPs (rs58402148; rs17014923).
CN cognitively normal participants, SCD participants with subjective cognitive decline, CSF cerebrospinal fluid, Aβ amyloid-β, p-tau phosphorylated tau protein, t-tau total tau protein, BIN1 bridging integrator 1 gene promoter, BIN1_01 01 region of bridging integrator 1 gene promoter.

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