Fig. 1: Test of whether BMI and WHR adiposity measures are causal risk factors for increase in appetite.

The panels plot per-allele effect sizes for a BMI, b WHR (x-axes) against per-allele effect size for increase in appetite (y-axis). For adiposity measures, effect sizes are measured in SDs, for increase in appetite symptom the effect size is log-odds ratio. For each plot, we estimated the slope using inverse-variance weighted regression (light blue line), simple-median regression (light green line), weighted-median regression (dark green line), and Egger regression (dark blue line).