Table 3 Results of the Mendelian Randomization analyses using the MR-Egger method in CoLaus|PsyCoLaus, NESDA|NTR, and in their combined dataset.

From: Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts

Dataset	Exposures	Outcomes	N SNPs	MR-Egger
				Intercept			Slope
				Beta	SE	p	Beta	SE	p
CoLaus\|PsyCoLaus + NESDA\|NTR combined	BMI	Atypical MDD vs controls	594	0.002	0.009	0.850	−0.236	0.547	0.666
		Non atypical MDD vs controls	593	−9E−05	0.005	0.987	0.045	0.329	0.891
		Increase in appetite	593	−0.003	0.011	0.778	0.855	0.660	0.196
		Hypersomnia	593	−0.008	0.009	0.398	0.493	0.563	0.382
		Mood reactivity	593	−0.013	0.007	0.064	0.527	0.439	0.231
		Leaden paralysis	593	0.011	0.008	0.169	−0.732	0.482	0.130
		Rejection sensitivity	593	−0.004	0.007	0.545	0.028	0.459	0.952
	WHR	Atypical MDD vs controls	330	−0.019	0.012	0.117	1.388	0.721	0.055
		Non atypical MDD vs controls	329	0.008	0.008	0.275	−0.586	0.462	0.206
		Increase in appetite	330	−0.027	0.015	0.067	2.309	0.885	0.009*
		Hypersomnia	331	0.004	0.013	0.750	0.223	0.779	0.775
		Mood reactivity	331	−0.007	0.010	0.521	0.778	0.627	0.216
		Leaden paralysis	331	0.013	0.011	0.218	−0.664	0.641	0.301
		Rejection sensitivity	330	−0.009	0.011	0.395	0.391	0.651	0.548
CoLaus\|PsyCoLaus	BMI	Atypical MDD vs controls	593	0.004	0.011	0.692	−0.012	0.690	0.986
		Non atypical MDD vs controls	593	0.009	0.008	0.218	−0.684	0.481	0.155
		Increase in appetite	592	0.003	0.013	0.831	0.660	0.793	0.405
		Hypersomnia	592	−0.011	0.011	0.330	0.985	0.694	0.156
		Mood reactivity	592	−0.022	0.010	0.024	1.448	0.605	0.017
		Leaden paralysis	592	0.009	0.011	0.406	−0.274	0.687	0.690
		Rejection sensitivity	591	−0.004	0.009	0.651	0.319	0.559	0.568
	WHR	Atypical MDD vs controls	330	−0.017	0.016	0.277	1.012	0.940	0.283
		Non atypical MDD vs controls	330	0.017	0.011	0.117	−1.161	0.648	0.074
		Increase in appetite	330	−0.035	0.020	0.081	2.540	1.195	0.034
		Hypersomnia	330	0.018	0.016	0.283	−0.769	0.986	0.436
		Mood reactivity	330	−0.008	0.015	0.575	0.520	0.886	0.558
		Leaden paralysis	330	0.019	0.015	0.203	−1.126	0.917	0.220
		Rejection sensitivity	330	−0.014	0.013	0.296	0.485	0.793	0.541
NESDA\|NTR	BMI	Atypical MDD vs controls	592	−0.004	0.015	0.808	−0.597	0.914	0.514
		Non atypical MDD vs controls	592	−0.008	0.007	0.256	0.656	0.443	0.139
		Increase in appetite	592	−0.018	0.019	0.349	1.402	1.187	0.238
		Hypersomnia	592	−0.002	0.015	0.886	−0.365	0.915	0.690
		Mood reactivity	591	−0.005	0.010	0.638	−0.384	0.623	0.538
		Leaden paralysis	592	0.013	0.012	0.275	−1.310	0.727	0.072
		Rejection sensitivity	592	−0.005	0.013	0.691	−0.620	0.786	0.431
	WHR	Atypical MDD vs controls	330	−0.018	0.020	0.353	1.825	1.171	0.120
		Non atypical MDD vs controls	330	0.005	0.011	0.627	−0.282	0.633	0.656
		Increase in appetite	330	−0.014	0.024	0.553	2.158	1.422	0.130
		Hypersomnia	330	−0.013	0.020	0.514	1.523	1.160	0.190
		Mood reactivity	330	−0.003	0.015	0.841	0.941	0.894	0.294
		Leaden paralysis	330	0.009	0.016	0.593	−0.250	0.967	0.796
		Rejection sensitivity	329	−0.006	0.017	0.714	0.408	1.025	0.691

Nominal significant associations are in bold and associations on symptoms surviving correction for multiple testing alpha level of 0.01 (0.05/5)) are denoted with an asterisk.
BMI body mass index, WHR waist-to-hip ratio.

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Table 3 Results of the Mendelian Randomization analyses using the MR-Egger method in CoLaus|PsyCoLaus, NESDA|NTR, and in their combined dataset.

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