Fig. 1: The Der1 mutation targets specific cell types in heterozygous cortex and hippocampus. | Translational Psychiatry

Fig. 1: The Der1 mutation targets specific cell types in heterozygous cortex and hippocampus.

From: Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness

Fig. 1

a Disc1 RNASeq reads normalised to total reads per sample in wild-type versus heterozygous Der1 cortex and hippocampus. b Heat maps of the top 500 dysregulated genes identified by RNASeq of wild-type versus heterozygous Der1 cortex and hippocampus. c, d EWCE analysis of heterozygous Der1 cortex and hippocampus, respectively, in mouse brain cell classes. Asterisk, significance after Bonferroni correction; Emb embryonic, Hyp hypothalamic, SD standard deviation. e Parvalbumin expression in hippocampal sections from 9-week-old mouse brain. Enlarged regions showing parvalbumin-expressing interneurons are indicated by boxes. Scale bars, 100 μm. f Average density of parvalbumin-expressing interneurons. Hippocampus refers to the whole hippocampal formation. Data were analysed by Kruskal–Wallis one-way ANOVA, p = 0.07 for the dentate gyrus, p = 0.049 for the hippocampal formation. The horizontal line on graphs for each sample, an average of values; WT wild type, HET heterozygous Der1, HOM homozygous Der1, DG dentate gyrus, *p < 0.05.

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