Fig. 3: The Der1 mutation dysregulates canonical pathways and genes related to schizophrenia and depression in heterozygous Der1 cortex. | Translational Psychiatry

Fig. 3: The Der1 mutation dysregulates canonical pathways and genes related to schizophrenia and depression in heterozygous Der1 cortex.

From: Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness

Fig. 3

a Canonical pathway predictions for putative schizophrenia risk genes, and for orthologues of putative schizophrenia and depression risk genes that are dysregulated at the whole-gene and exon-level, as identified using DESeq2 + DEXSeq data. b, c Altered schizophrenia risk gene orthologue expression in the ‘Synaptic long-term depression’ and ‘CREB signalling in neurons’ canonical pathways, respectively. Double outlines indicate protein complexes and classes, the components of which can be found in Supplementary Table 2a, b. To provide additional information, genes encoding ionotropic glutamate receptor δ subunits (Grid), AMPA receptor subunits (AMPAR), voltage-gated calcium channel subunits (VGCC), calcium channels (CaCh), ionotropic glutamate receptor subunits (iGLUR) and structural synaptic components have been added to the pathways using the IPA ‘Build’ tool. *Genes identified by DEXSeq; red, dysregulated putative schizophrenia risk gene orthologue.

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