Table 1 Methodological summary of the studies.

From: Magnetic resonance imaging for individual prediction of treatment response in major depressive disorder: a systematic review and meta-analysis

Study + year	n	Outcome	Intervention	Duration	Modality	Analysis	Validation
Costafreda et al. 2009—1	16	Remission	CBT	16 wk	tbfMRI	SVM	LOO CV
Siegle et al. 2012	12	Response	CBT	12 wk	tbfMRI	RF	Ind. replication
Queirazza et al. 2019	37	Response	CBT	6–10 wk	tbfMRI	SVM, LR	LOO nested CV
Van Waarde et al. 2015	45	Remission	ECT	10 wk	rsfMRI	lSVM	LOO CV
Moreno-Ortega et al. 2019	19	Remission	ECT	ns	rsfMRI	LR	LOO CV
Sun et al. 2019	122	Remission + remission	ECT	3–4 wk	rsfMRI	LR	LOO CV
Redlich et al. 2016	23	Response	ECT	3–8 wk	sMRI	lSVM/GPC	LOO CV
Wade et al. 2016	34	Response	ECT	2–7 wk	sMRI	RBFSVM	LOO CV
Cao et al. 2018	24	Response + remission	ECT	3–4 wk	sMRI	lSVM	LOO CV
Jiang et al. 2018	38	Remission	ECT	3–4 wk	sMRI	LR	10-fold LOO CV+ Independent cohort rep
Wade et al. 2017 Leaver et al. 2017	44^a	Remission Response	ECT ECT	ns ns	sMRI rsfMRI, aslMRI	RF RBFSVM	Nested CV 5-fold LOO CV
Drysdale et al. 2017	124 30	Response	rTMS	4–6 wk	rsfMRI	lSVM	LOO CV Ind. replication
Cash et al. 2019	33	Remission	rTMS	5–8 wk	rsfMRI	lSVM	LOO + k fold CV
Costafreda et al. 2009—2 Nouretdinov et al. 2011	18^a	Remission Remission	SSRI SSRI	8 wk 8 wk	sMRI sMRI	lSVM TCP	LOO CV LOO CV
Gong et al. 2011	46	Response	SSRI/TCA/SNRI	12 wk	sMRI	lSVM	LOO CV
Marquand et al. 2008	20	Response	SSRI	8 wk	tbfMRI	lSVM	LOO CV
Godlewska et al. 2018	32	Response	SSRI	6 wk	tbfMRI	LR	LOO CV
Meyer et al. 2019	22	Remission/non-response	SSRI	8 wk	tbfMRI	LR	LOO CV
Karim et al. 2018	49	Remission	SNRI	12 wk	tbfMRI	LR	10-fold LOO CV
Patel et al. 2015	19	Remission	SSRI/SNRI	ns	rsfMRI, DTI, sMRI	ADTree/lSVM/RBFSVM/L1LR	Nested LOO CV
iSPOT trials	77^a		SSRI/SNRI	8 wk
Korgaonkar et al. 2014		Remission			DTI	LR	K-fold CV
Williams et al. 2015		Response			tbfMRI	LDA	LOO CV
Goldstein-Piekarski et al. 2016		Remission			tbfMRI	LR	10-fold LOO CV
Grieve et al. 2016		Non-remission			DTI	LR	Independent rep
Goldstein-Piekarski et al. 2018		Remission			rsfMRI	LR	LOO CV

Reported sample sizes were not necessarily equal in articles with overlapping sample.
SSRI selective serotonin reuptake inhibitor, TCA tricyclic antidepressant, SNRI serotonin-norepinephrine reuptake inhibitor, ECT electroconvulsive therapy, CBT cognitive behavioral therapy, rTMS repetitive transcranial magnetic stimulation, iTBS intermittent theta burst stimulation, AP antipsychotics, ns not specified, tb task based, rs resting state, asl arterial spin labeling, fMRI functional magnetic resonance imaging, sMRI structural magnetic resonance imaging, WB whole brain, ROI region of interest, DTI diffusion tensor imaging, lSVM linear support vector machine, RBF radial basic function, TCP transductive conformal predictor, LR logistic regression, LinR linear regression, LDA linear discriminant analysis, RF random forest, LOO CV leave-one-out cross-validation, wm white matter, sLR stepwise linear regression, beta-w beta-weights, LARS least-angle regression, PMVD proportional marginal decomposition.
^an is a weighted average across studies.

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Table 1 Methodological summary of the studies.

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