Fig. 2: Localisation of electrodes and active contacts. | Translational Psychiatry

Fig. 2: Localisation of electrodes and active contacts.

From: A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder

Fig. 2

DBS electrodes were localised with the Lead-DBS toolbox and represented in common ICBM 2009b nonlinear asymmetric space incorporating a 7-Tesla MRI at 100 micron resolution73 with subcortical parcellations derived from a recent high-resolution atlas74. A Three-dimensional reconstruction in the coronal plane showing electrode trajectories for the nine participants. B Three-dimensional reconstruction in the axial plane showing the distribution of the aggregated stimulation field across the cohort (red), which can be seen to encompass the posterior segment of the nucleus accumbens (light green), the ventral pallidum (yellow) and the hypothalamus (blue). C Two-dimensional reconstruction of active contacts in coronal plane. D Two-dimensional reconstruction of active contacts in axial plane. E, F Two-dimensional reconstruction of active contacts in sagittal plane. In the two-dimensional representations, coloured circles represent the second most inferior contact on each electrode (i.e. contact 9 on right electrode and contact 1 on left electrode). Ca caudate, EXA extended amygdala (BNST), GPe globus pallidus external segment, HTH hypothalamus, NAC nucleus accumbens, PBP parabrachial pigmented nucleus, Pu putamen, SN substantia nigra, STH subthalamic nucleus, RN red nucleus, VeP ventral pallidum.

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