Table 1 Details of participants.
Participant age and gender | OCD phenomenology; age of onset; previous therapiesa ; comorbidities and YBOCS at baseline | Psychotropic medication and chronic stimulation parametersb | Percentage YBOCS and MADRS reduction at end of open phase | Serious adverse events | Adverse events |
|---|---|---|---|---|---|
1 28 Female | Contamination Onset age 10 4 antidepressants / 3 antipsychotics Major depressive disorder YBOCS 32 | Clomipramine 150 mg Quetiapine 100 mg Olanzapine 5 mg DBS Right hemisphere: C+ 8–9–4.5 V/90 µs/130 Hz DBS Left hemisphere: C+ 0–1–4.5 V/90 µs/130 Hz | YBOCS = 53.1 MADRS = 57.1 | Nil | Parasomnia (sleepwalking) |
2 29 Male | Harming others/Sexuality/Blasphemy Onset age 9 16 antidepressants / 3 antipsychotics/ECT Major depressive disorder YBOCS 33 | Tranylcypromine 30 mg Nortriptyline 75 mg Diazepam 5 mg DBS Right hemisphere: C+ 9–3.5 V/90 µs/130 Hz DBS Left hemisphere: C+ 1–3.5 V/90 µs/130 Hz | YBOCS = 69.7 MADRS = 70.6 | Deviation of one DBS electrode during implantation requiring removal and reimplantation. | Pustule at IPG site Lead tightening behind ear Reduced libido Mild agitation at higher stimulation amplitudes |
3 57 Male | Sexuality Onset age 19 12 antidepressants / 7 antipsychotics Nil YBOCS 29 | Clomipramine 50 mg DBS Right hemisphere: C+ 9–4.5 V/90 µs/130 Hz DBS Left hemisphere: C+ 1–4.5 V/90 µs/130 Hz | YBOCS = 51.7 MADRS = 50.0 | Nil | Nil |
4 54 Male | Harming others Onset age 16 9 antidepressants / 4 antipsychotics / ECT Major depressive disorder YBOCS 35 | Clomipramine 200 mg Quetiapine XR 400 mg Clonazepam 1.5 mg DBS Right hemisphere: C+ 9–10–4.7 V/90 µs/130 Hz DBS Left hemisphere: C+ 1–2–4.7 V/90 µs/130 Hz | YBOCS = 54.3 MADRS = 35.3 | Two inpatient psychiatric admissions to manage recurrence of depressive symptoms | Nil |
5 57 Female | Sexuality/Symmetry Onset age 6 9 antidepressants / 4 antipsychotics / ECT / rTMS Major depressive disorder / body dysmorphic disorder YBOCS 32 | Sertraline 100 mg Pregabalin 150 mg Clonazepam 0.25 mg DBS Right hemisphere: C+ 9–4.5 V/90 µs/130 Hz DBS Left hemisphere: C+ 1–4.5 V/90 µs/130 Hz | YBOCS = 28.1 MADRS = 46.2 | Infection of IPG requiring DBS device explantation | Nil |
6 47 Female | Contamination Onset aged 8 19 antidepressants / 5 antipsychotics / ECT / rTMS Major depressive disorder YBOCS 28 | Tranylcypromine 10 mg Imipramine 50 mg Clonazepam 0.5 mg Olanzapine 10 mg Quetiapine IR 100 mg Lithium XR 450 mg DBS Right hemisphere: C+ 10–5.6 V/120 µs/130 Hz DBS Left hemisphere: C+ 1–5.6 V/120 µs/130 Hz | YBOCS = 0 MADRS = −4.0 | Five inpatient psychiatric admissions to manage persistence of obsessive & depressive symptoms | Nil |
7 54 Male | Doubt/Perfectionism Onset aged 7 3 antidepressants / 2 antipsychotics Nil YBOCS 35 | Clomipramine 50 mg Sertraline 250 mg DBS Right hemisphere: C+ 9–10–4.5 V/90 µs/130 Hz DBS Left hemisphere: C+ 1–2–4.5 V/90 µs/130 Hz | YBOCS = 48.6 MADRS = 80.0 | Nil | Nil |
8 48 Female | Checking/Magical thinking Onset aged 5 8 antidepressants / 3 antipsychotics/ECT Major depressive disorder YBOCS 34 | Clomipramine 125 mg Desvenlafaxine 200 mg Olanzapine 5 mg DBS Right Hemisphere: C+ 9–10–4.5 V/90 µs/130 Hz DBS Left hemisphere: C+ 1–2–4.5 V/90 µs/130 Hz | YBOCS = 82.3 MADRS = 78.9 | Nil | Nil |
9 55 Male | Checking/Doubt Onset aged 7 5 antidepressants / 2 antipsychotics Nil YBOCS 36 | Fluoxetine 80 mg Dexamphetamine 60 mg DBS Right hemisphere: C+ 9–10–5.0 V/90 µs/130 Hz DBS Left hemisphere: C+ 1–2–5.0 V/90 µs/130 Hz | YBOCS = 58.3 MADRS = 77.8 | Nil | Nil |
