Fig. 3: Analyses of age-by-diagnosis and age-by-SNP effects on the component of the common neurobiological substrate (CCS).
From: Genetic factors influencing a neurobiological substrate for psychiatric disorders
A A significant smaller CCS was observed in MDD (BiDirect, MPIP, FOR2107), BD (FOR2107), SZA (FOR2107), and SCZ (FOR2107) patients, affirming the transdiagnostic finding by Goodkind et al.1 (Supplementary Table S15). B Age2 trajectories of the patient/control groups plotted for each cohort. A non-linear, quadratic age dependency was observed in MDD (pooled MPIP, BiDirect, FOR2107), but no other diagnostic group. Data points represent the CCS after residualization against all covariates except for age and age2 (separate fit for patients and controls (Supplementary Table S15). C Age-stratified analyses of the association between diagnosis and the CCS using five age groups in the combined patient/control cohorts (with cohort as a covariate). No significant heterogeneity was observed. Size and color of the effect sizes per bin are proportional to the sample size. D Age-stratified analyses of the association between the top SNP (rs17076061) and the CCS using five age groups in the combined five population-based GWAS cohorts (with cohort modeled as a covariate). No significant heterogeneity between the age groups was observed. Size and color of the effect sizes per bin are proportional to the sample size.
