Table 5 Schizophrenia PRS modulates the association of cannabis use with self-reported psychotic experiences.
Prevalence of self-reported psychotic experiences (ever- vs. never-users), stratified by schizophrenia PRS | PRS-by-ever-use interaction | PRS-by-frequency interaction | |||||
|---|---|---|---|---|---|---|---|
0–20th Percentile SCZ PRS | 20–40th Percentile SCZ PRS | 40–60th Percentile SCZ PRS | 60–80th Percentile SCZ PRS | 80–100th Percentile SCZ PRS | |||
Any psychotic experience | 5.8 vs. 3.6% AOR = 1.39 [1.16, 1.65] | 6.7 vs. 4.0% AOR = 1.48 [1.26, 1.74] | 7.0 vs. 4.2% AOR = 1.52 [1.30, 1.78] | 7.5 vs. 4.3% AOR = 1.64 [1.40, 1.91] | 8.2 vs. 4.7% AOR = 1.58 [1.36, 1.83] | FDR = 9% (p = 0.02) | FDR = 2% (p = 0.01) |
Auditory hallucinations | 2.2 vs. 1.2% AOR = 1.36 [1.02, 1.82] | 2.4 vs. 1.4% AOR = 1.32 [1.01, 1.73] | 2.7 vs. 1.5% AOR = 1.54 [1.20, 1.98] | 2.8 vs. 1.3% AOR = 1.91 [1.47, 2.48] | 3.2 vs. 1.5% AOR = 1.73 [1.36, 2.22] | FDR = 9% (p = 0.04) | FDR = 2% (p = 0.01) |
Visual hallucinations | 3.7 vs. 2.4% AOR = 1.46 [1.18, 1.81] | 4.6 vs. 2.7% AOR = 1.63 [1.34, 1.98] | 4.5 vs. 2.7% AOR = 1.52 [1.25, 1.85] | 4.9 vs. 3.0% AOR = 1.59 [1.31, 1.91] | 5.2 vs. 3.0% AOR = 1.66 [1.38, 1.99] | FDR = 17% (p = 0.1) | FDR = 7% (p = 0.06) |
Persecutory delusions | 0.8 vs. 0.4% AOR = 1.60 [0.98, 2.60] | 1.3 vs. 0.4% AOR = 2.30 [1.53, 3.45] | 1.1 vs. 0.6% AOR = 1.65 [1.11, 2.44] | 1.4 vs. 0.6% AOR = 1.39 [0.96, 2.00] | 1.7 vs. 0.9% AOR = 1.36 [0.97, 1.89] | FDR = 99% (p = 1) | FDR = 29% (p = 0.3) |
Delusions of reference | 0.5 vs. 0.4% AOR = 1.07 [0.63, 1.82] | 0.7 vs. 0.5% AOR = 1.29 [0.82, 2.05] | 0.8 vs. 0.6% AOR = 1.07 [0.69, 1.67] | 1.1 vs. 0.6% AOR = 1.54 [1.04, 2.28] | 1.5 vs. 0.7% AOR = 1.68 [1.18, 2.38] | FDR = 9% (p = 0.05) | FDR = 0.4% (p = 0.0007) |
