Fig. 3: Prioritizing genes around RP1-265C24.5 in pleiotropic association with MDD. | Translational Psychiatry

Fig. 3: Prioritizing genes around RP1-265C24.5 in pleiotropic association with MDD.

From: Mendelian randomization integrating GWAS and eQTL data revealed genes pleiotropically associated with major depressive disorder

Fig. 3

A Cortex. B Nucleus accumbens. Top plot, gray dots represent the −log10(P values) for SNPs from the GWAS of MDD, and rhombuses represent the −log10(P values) for probes from the SMR test with solid rhombuses indicating that the probes pass HEIDI test and hollow rhombuses indicating that the probes do not pass the HEIDI test. Middle plot, eQTL results for the probe ENSG00000219392.1 tagging RP1-265C24.5. Bottom plot, location of genes tagged by the probe. Highlighted in maroon indicates probes that pass the SMR threshold. GWAS genome-wide association studies, MDD major depressive disorder, SMR summary data-based Mendelian randomization, HEIDI heterogeneity in dependent instruments, eQTL expression quantitative trait loci.

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