Table 3 Nominally significantly differential association of the AD risk PRS with lipids between AD and controls control.

From: Plasma lipidome is dysregulated in Alzheimer’s disease and is associated with disease risk genes

Lipid

Beta.PRS

Beta.PRS_CC

SE.PRS

SE.PRS_CC

t.PRS

t.PRS_CC

Pval.PRS

Pval.PRS_CC

Cer(d18:1_16:0)

0.197

−0.511

0.133

0.195

1.483

−2.624

0.142

0.011

Cer(t16:1_14:0)

0.268

−0.510

0.141

0.207

1.894

−2.461

0.062

0.016

ChE(22:5)

−0.080

0.539

0.137

0.200

−0.583

2.690

0.562

0.009

PC(16:0_20:4)

−0.107

0.495

0.144

0.211

−0.745

2.345

0.459

0.022

PC(16:0_20:5)

0.001

0.535

0.144

0.210

0.007

2.544

0.994

0.013

PC(16:0_22:6)

0.150

0.419

0.123

0.180

1.221

2.331

0.226

0.022

PC(16:2e_16:0)

0.089

−0.428

0.145

0.212

0.612

−2.018

0.543

0.047

PC(18:0_20:3)

0.131

0.433

0.135

0.198

0.973

2.187

0.334

0.032

PC(18:1_20:3)

0.025

0.441

0.143

0.209

0.174

2.108

0.863

0.038

PC(18:2_18:2)

−0.005

0.415

0.138

0.202

−0.039

2.053

0.969

0.044

PC(34:0)

0.057

−0.510

0.142

0.208

0.404

−2.447

0.688

0.017

PC(37:2)

0.285

−0.488

0.147

0.215

1.942

−2.267

0.056

0.026

PE(16:0_20:3)

−0.059

0.445

0.144

0.210

−0.413

2.117

0.681

0.038

PI(18:0_18:2)

0.026

−0.421

0.123

0.180

0.208

−2.346

0.836

0.022

PI(36:3)

−0.163

0.603

0.148

0.217

−1.105

2.784

0.273

0.007

SM(d17:1_13:0)

0.353

−0.668

0.142

0.209

2.476

−3.200

0.016

0.002

SM(d17:1_18:3)

0.041

−0.405

0.134

0.196

0.303

−2.064

0.763

0.043

SM(d18:2_24:3)

0.240

−0.470

0.145

0.213

1.653

−2.207

0.103

0.030

SM(d32:4)

0.166

−0.585

0.134

0.197

1.233

−2.971

0.222

0.004

SM(d33:1)

0.095

−0.521

0.139

0.204

0.683

−2.551

0.497

0.013

SM(d34:2)

0.132

−0.416

0.141

0.206

0.933

−2.014

0.354

0.048

SM(d35:1)

0.204

−0.462

0.148

0.216

1.384

−2.134

0.171

0.036

SM(d36:3)

0.365

−0.568

0.146

0.213

2.506

−2.662

0.014

0.010

SM(d37:2)

−0.012

−0.429

0.136

0.199

−0.090

−2.161

0.929

0.034

SM(d38:1)

0.006

−0.419

0.127

0.186

0.049

−2.250

0.961

0.027

SM(d38:2)

0.027

−0.458

0.137

0.200

0.197

−2.285

0.844

0.025

SM(d39:1)

−0.031

−0.413

0.131

0.192

−0.240

−2.153

0.811

0.035

SM(d39:2)

0.108

−0.516

0.139

0.203

0.776

−2.539

0.440

0.013

SM(d40:1)

0.038

−0.453

0.135

0.198

0.283

−2.294

0.778

0.025

SM(d40:3)

0.118

−0.458

0.149

0.218

0.789

−2.098

0.433

0.039

SM(d41:4)

−0.070

−0.397

0.135

0.198

−0.520

−2.003

0.605

0.049

SM(d42:1)

0.103

−0.435

0.138

0.202

0.746

−2.152

0.458

0.035

SM(d42:2)

0.028

−0.507

0.129

0.189

0.221

−2.688

0.826

0.009

SM(d42:3)

0.041

−0.494

0.140

0.205

0.296

−2.409

0.768

0.018

SM(d43:1)

0.106

−0.500

0.147

0.215

0.721

−2.328

0.473

0.023

SM(d43:2)

0.167

−0.606

0.140

0.204

1.200

−2.966

0.234

0.004

SM(d44:4)

0.019

−0.421

0.136

0.200

0.143

−2.107

0.887

0.038

SM(d44:5)

0.134

−0.575

0.131

0.192

1.028

−3.001

0.308

0.004

SM(d44:6)

0.054

−0.427

0.139

0.204

0.389

−2.092

0.699

0.040

SM(t18:0_24:2)

0.163

−0.509

0.143

0.209

1.145

−2.436

0.256

0.017

SM(t42:1)

0.240

−0.578

0.139

0.204

1.724

−2.832

0.089

0.006

TG(12:0_17:1_18:2)

−0.122

0.473

0.144

0.211

−0.848

2.243

0.399

0.028

TG(12:0_18:2_18:2)

−0.159

0.555

0.134

0.196

−1.191

2.832

0.237

0.006

TG(14:0_14:3_18:2)

−0.136

0.470

0.143

0.209

−0.950

2.250

0.345

0.027

TG(14:0_18:3_18:3)

−0.046

0.518

0.135

0.197

−0.345

2.623

0.731

0.011

TG(15:0_14:1_16:1)

−0.048

0.463

0.129

0.189

−0.375

2.453

0.709

0.017

TG(15:0_16:0_20:5)

−0.063

0.480

0.133

0.195

−0.474

2.464

0.637

0.016

TG(16:0_14:0_18:3)

−0.142

0.468

0.138

0.202

−1.032

2.317

0.305

0.023

TG(16:0_14:1_16:1)

−0.198

0.579

0.146

0.213

−1.360

2.711

0.178

0.008

TG(16:1_12:0_18:2)

−0.046

0.421

0.142

0.208

−0.324

2.023

0.747

0.047

TG(16:1_20:5_20:5)

0.088

0.503

0.126

0.185

0.696

2.724

0.488

0.008

TG(18:3_14:1_18:2)

−0.045

0.412

0.141

0.206

−0.319

1.999

0.751

0.049

TG(18:4_14:0_16:1)

−0.155

0.616

0.143

0.209

−1.082

2.944

0.283

0.004

TG(18:4_16:0_20:4)

−0.081

0.525

0.141

0.207

−0.571

2.533

0.570

0.013

TG(20:1_20:4_20:4)

0.304

−0.531

0.144

0.210

2.117

−2.524

0.038

0.014

TG(22:5_18:2_18:2)

−0.078

0.454

0.147

0.215

−0.529

2.110

0.598

0.038

TG(33:4e)

−0.160

0.651

0.137

0.201

−1.168

3.241

0.247

0.002

  1. Marginal effect: Beta.PRS/SE.PRS/t.PRS/Pval. PRS: Beta coefficient/standard error/t statistics/p value of association between PRS scores and individual lipids.
  2. Interaction effect: Beta.PRS_CC/SE.PRS_CC/t.PRS_CC/Pval.PRS_CC: Beta coefficient/standard error/t statistics/p value of differential association of PRS with lipids between AD and controls control.
  3. Cer ceramides, SM sphingomyelins, ChE cholesteryl esters, DG diglycerides, TG triglycerides, PC phosphatidylcholines, LPC lyso-phosphatidylcholines, PE phosphatidylethanolamines, PI phosphatidylinositols.
Back to article page