Table 5 Overlap of lipids with significant association with SNPs and PRS scores.
From: Plasma lipidome is dysregulated in Alzheimer’s disease and is associated with disease risk genes
Lipid | Number of associated SNPs | Most significant Pval.SNPs | Gene (minimum Pvalue.SNPs) | Pval.PRS_CC |
|---|---|---|---|---|
Cer(d18:1_16:0) | 3 | 0.009 | CLU | 0.011 |
ChE(22:5) | 5 | 0.014 | SORL1 | 0.009 |
PC(16:0_20:4) | 1 | 0.045 | CASS4 | 0.022 |
PC(16:0_20:5) | 2 | 0.033 | SORL1 | 0.013 |
PC(18:0_20:3) | 1 | 0.027 | MS4A6A | 0.032 |
PC(18:1_20:3) | 1 | 0.042 | CELF1 | 0.022 |
PC(18:2_18:2) | 1 | 0.007 | FERMT2 | 0.044 |
PE(16:0_20:3) | 1 | 0.005 | CR1 | 0.038 |
PI(36:3) | 1 | 0.002 | INPP5D | 0.007 |
SM(d17:1_13:0) | 2 | 0.014 | SORL1 | 0.002 |
SM(d17:1_18:3) | 3 | 0.040 | CLU | 0.043 |
SM(d32:4) | 3 | 0.008 | MS4A6A | 0.004 |
SM(d33:1) | 5 | 0.021 | CLU | 0.013 |
SM(d34:2) | 2 | 0.045 | CLU | 0.048 |
SM(d35:1) | 1 | 0.012 | MS4A6A | 0.036 |
SM(d37:2) | 4 | 0.014 | CD2AP | 0.034 |
SM(d38:1) | 3 | 0.041 | CLU | 0.027 |
SM(d38:2) | 3 | 0.022 | CLU | 0.025 |
SM(d39:1) | 3 | 0.027 | CLU | 0.035 |
SM(d39:2) | 3 | 0.027 | CLU | 0.013 |
SM(d40:1) | 5 | 0.021 | CLU | 0.025 |
SM(d41:4) | 1 | 0.028 | MS4A6A | 0.049 |
SM(d42:1) | 2 | 0.013 | MS4A6A | 0.035 |
SM(d42:2) | 5 | 0.012 | MS4A6A | 0.009 |
SM(d42:3) | 3 | 0.044 | ABCA7 | 0.018 |
SM(d43:1) | 2 | 0.030 | CD2AP | 0.023 |
SM(d43:2) | 1 | 0.032 | CASS4 | 0.004 |
SM(d44:4) | 3 | 0.016 | CLU | 0.038 |
SM(d44:5) | 4 | 0.026 | CLU | 0.004 |
SM(t18:0_24:2) | 3 | 0.022 | MS4A6A | 0.017 |
SM(t42:1) | 5 | 0.023 | MS4A6A | 0.006 |
TG(12:0_17:1_18:2) | 1 | 0.013 | NME8 | 0.028 |
TG(14:0_14:3_18:2) | 1 | 0.037 | BIN1 | 0.027 |
TG(14:0_18:3_18:3) | 3 | 0.003 | NME8 | 0.011 |
TG(15:0_14:1_16:1) | 1 | 0.032 | NME8 | 0.017 |
TG(15:0_16:0_20:5) | 2 | 0.048 | BIN1 | 0.016 |
TG(16:0_14:0_18:3) | 5 | 0.011 | CLU | 0.023 |
TG(16:0_14:1_16:1) | 1 | 0.018 | SORL1 | 0.008 |
TG(18:3_14:1_18:2) | 2 | 0.035 | ABCA7 | 0.049 |
TG(18:4_14:0_16:1) | 1 | 0.045 | ZCWPW1 | 0.004 |
TG(18:4_16:0_20:4) | 3 | 0.011 | CLU | 0.013 |
TG(22:5_18:2_18:2) | 4 | 0.017 | NME8 | 0.038 |
TG(33:4e) | 4 | 0.011 | MS4A6A | 0.002 |
