Fig. 2: Years of crack-cocaine use and FA.

A Association between years of crack-cocaine use and decrease in FA, as revealed by whole-brain average FA and TBSS analysis. Areas with the significant negative association in heat scale, the skeleton in green projected onto CUD’s average FA image. Sagittal view: x = 62; axial view: z = 86. B Main cluster comprising the genu and body of the corpus callosum, in which there was a strong negative association between the years of crack-cocaine use and FA. Center of mass at MNI coordinates: x = 94, y = 155, z = 81. FA fractional anisotropy, TBSS tract-based special statistics, CUD cocaine use disorder.