Table 1 Participant characteristics.

From: Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease

 

All

Participants without dementia diagnosis

Aβ+

Aβ−

Aβ +

Aβ−

p-valuea

p-valueb

n

114

614

62

519

  

Age, mean ± SD (range)

68.4 ± 4.8 (54–75)

68.5 ± 4.7 (52–75)

67.9 ± 5.1 (54–75)

68.4 ± 4.7 (53–75)

0.81

0.44

≤70 years, n (%)

59 (51.8)

307 (50.0)

36 (58.1)

262 (50.5)

0.73

0.26

>70 years, n (%)

55 (48.3)

307 (50.0)

26 (41.9)

257 (49.5)

  

Male, n (%)

57 (50.0)

251 (40.9)

34 (54.8)

210 (40.5)

0.07

0.03

Female, n (%)

57 (50.0)

363 (59.1)

28 (45.2)

309 (59.5)

  

≤9 yrs education, n (%)

99 (86.8)

533 (88.1)

54 (87.1)

452 (87.8)

0.12

0.45

10–11 yrs education, n (%)

5 (4.4)

44 (7.3)

3 (4.8)

38 (7.4)

  

≥12 yrs education, n (%)

10 (8.8)

28 (4.6)

5 (8.1)

25 (4.8)

  

Aβ PRS−, n (%)

83 (72.8)

461 (75.1)

48 (77.4)

389 (75.0)

0.61

0.67

Aβ PRS+, n (%)

31 (27.2)

153 (24.9)

14 (22.6)

130 (25.0)

  

AD PRS−, n (%)

76 (66.7)

460 (74.9)

45 (72.6)

392 (75.5)

0.07

0.61

AD PRS+, n (%)

38 (33.3)

154 (25.1)

17 (27.4)

127 (24.5)

  

APOE4−, n (%)

74 (64.9)

460 (74.9)

43 (69.4)

395 (76.1)

0.03

0.24

APOE4+, n (%)

40 (35.1)

154 (25.1)

19 (30.6)

124 (23.9)

  

Aβ PRS− APOE4−, n (%)

69 (60.5)

408 (66.5)

40 (64.5)

348 (67.0)

0.10

0.40

Aβ PRS+ APOE4−, n (%)

5 (4.4)

52 (8.5)

3 (4.8)

47 (9.1)

  

Aβ PRS− APOE4+, n (%)

14 (12.3)

53 (8.6)

8 (12.9)

41 (7.9)

  

Aβ PRS+ APOE4+, n (%)

26 (22.8)

101 (16.5)

11 (17.8)

83 (16.0)

  

AD PRS− APOE4−, n (%)

68 (59.7)

413 (67.2)

40 (64.5)

354 (68.2)

0.06

0.57

AD PRS+ APOE4−, n (%)

6 (5.3)

47 (7.7)

3 (4.8)

41 (7.9)

  

AD PRS− APOE4+, n (%)

8 (7.0)

47 (7.7)

5 (8.1)

38 (7.3)

  

AD PRS+ APOE4+, n (%)

32 (28.1)

107 (17.4)

14 (22.6)

86 (16.6)

  

AD PRS− Aβ PRS−, n (%)

70 (61.4)

408 (66.5)

42 (67.8)

348 (67.0)

0.25

0.76

AD PRS+ Aβ PRS−, n (%)

13 (11.4)

53 (8.6)

6 (9.7)

44 (8.5)

  

AD PRS− Aβ PRS+, n (%)

6 (5.3)

52 (8.5)

3 (4.8)

41 (7.9)

  

AD PRS+ Aβ PRS+, n (%)

25 (21.9)

101 (16.5)

11 (17.7)

86 (16.6)

  
  1. p-values reported are for comparisons between Aβ misfolding positive and negative participants for entire samplea and participants without dementia diagnosisb.
  2. Aβ+ Aβ misfolding positive, Aβ− Aβ misfolding negative, Aβ PRS Aβ specific polygenic risk score, AD PRS Alzheimer’s disease polygenic risk score, APOE apolipoprotein E
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