Table 2 Logistic regression results: Association between Alzheimer’s and Aβ polygenic risk scores and Aβ misfolding.

	All, n = 728				Participants without dementia diagnosis, n = 581
	n, Aβ+	n, Aβ−	OR (95% CI)	p-value	n, Aβ+	n, Aβ−	OR (95% CI)	p-value
Aβ PRS per SD	114	614	1.05 (0.85-1.29)	0.67	62	519	1.03 (0.77–1.38)	0.85
Aβ PRS per SD*	114	614	0.89 (0.70–1.15)	0.38	62	519	0.95 (0.67-1.32) +4)	0.74
AD PRS per SD	114	614	1.25 (1.03–1.51)	0.03	62	519	1.04 (0.78–1.38)	0.79
AD PRS per SD*	114	614	1.16 (0.90–1.48)	0.25	62	519	0.95 (0.67–1.34)	0.75
Aβ PRS−	83	461	Ref.		48	389	Ref.
Aβ PRS+	31	153	1.14 (0.72–1.81)	0.58	14	130	0.85 (0.44–1.64)	0.64
AD PRS−	76	460	Ref.		45	392	Ref.
AD PRS+	38	154	1.58 (1.01–2.46)	<0.05	17	127	1.13 (0.61–2.12)	0.70
APOE4−	74	460	Ref.		43	395	Ref.
APOE4+	40	154	1.61 (1.04–2.49)	0.03	19	124	1.33 (0.72–2.46)	0.36
Aβ PRS− APOE4−	69	408	Ref.		40	348	Ref.
Aβ PRS+ APOE4−	5	52	0.53 (0.20–1.40)	0.20	3	47	0.51 (0.15–1.76)	0.29
Aβ PRS− APOE4+	14	53	1.43 (0.73–2.79)	0.30	8	41	1.46 (0.59–3.61)	0.41
Aβ PRS+ APOE4+	26	101	1.57 (0.94–2.62)	0.09	11	83	1.14 (0.54–2.39)	0.74
AD PRS− APOE4−	68	413	Ref.		40	354	Ref.
AD PRS+ APOE4−	6	47	0.76 (0.30–1.89)	0.55	3	41	0.54 (0.15–1.96)	0.35
AD PRS− APOE4+	8	41	0.88 (0.39–2.00)	0.76	5	38	0.94 (0.33–2.73)	0.91
AD PRS+ APOE4+	32	107	1.92 (1.18–3.12)	<0.01	14	86	1.43 (0.72–2.85)	0.31
AD PRS− Aβ PRS−	70	408	Ref.		42	348	Ref.
AD PRS+ Aβ PRS−	13	53	1.46 (0.73–2.91)	0.28	6	44	1.05 (0.39–2.81)	0.92
AD PRS− Aβ PRS+	6	52	0.62 (0.25–1.53)	0.30	3	41	0.51 (0.15–1.73)	0.28
AD PRS+ Aβ PRS+	25	101	1.53 (0.91–2.57)	0.11	11	86	1.07 (0.51–2.25)	0.86

Model covariates included age, sex, education and 10 principal components.
Bolded results indicate statistical significance, p < 0.05.
*Additionally adjusted for APOE status
Aβ+ Aβ misfolding positive, Aβ− Aβ misfolding negative, APOE4+, apolipoprotein E ≥ 1 ε4 allele, PRS genetic risk score, Ref. reference, SD standard deviation.

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