Table 3 Logistic regression results: prediction of AD and VD diagnoses by Alzheimer’s and Aβ polygenic risk.

From: Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease

 

AD Diagnosis

VD Diagnosis

AD

ND

OR (95% CI)

p-value

VD

ND

OR (95% CI)

p-value

Aβ PRS per SD

59

581

1.32 (1.01–1.73)

<0.05

54

581

1.05 (0.78–1.42)

0.76

Aβ PRS per SD*

59

581

1.02 (0.74–1.40)

0.93

54

581

0.98 (0.69–1.41)

0.92

AD PRS per SD

59

581

1.47 (1.16–1.87)

<0.01

54

581

1.13 (0.85–1.50)

0.41

AD PRS per SD*

59

581

1.21 (0.89–1.66)

0.22

54

581

1.09 (0.75–1.59)

0.64

Aβ PRS−

37

437

Ref.

 

41

437

Ref.

 

Aβ PRS+

22

144

1.85 (1.05–3.28)

0.04

13

144

0.90 (0.46–1.77)

0.76

AD PRS−

34

437

Ref.

 

37

437

Ref.

 

AD PRS+

25

144

2.29 (1.30–4.02)

<0.01

17

144

1.34 (0.71–2.50)

0.37

APOE4−

32

438

Ref.

 

37

438

Ref.

 

APOE4+

27

143

2.69 (1.54–4.72)

<0.001

17

143

1.26 (0.67–2.37)

0.47

Aβ PRS− APOE4−

28

388

Ref.

 

34

388

Ref.

 

Aβ PRS+ APOE4−

4

50

1.09 (0.36–3.28)

0.88

3

50

0.60 (0.17–2.14)

0.43

Aβ PRS− APOE4+

9

49

2.61 (1.14–5.98)

0.02

7

49

1.37 (0.54–3.48)

0.51

Aβ PRS+ APOE4+

18

94

2.78 (1.45–5.32)

<0.01

10

94

1.11 (0.52–2.38)

0.79

AD PRS− APOE4−

29

394

Ref.

 

32

394

Ref.

 

AD PRS+ APOE4−

3

44

0.92 (0.26–3.21)

0.89

5

44

1.58 (0.56–4.47)

0.39

AD PRS− APOE4+

5

43

1.66 (0.59–4.65)

0.35

5

43

1.33 (0.47–3.79)

0.59

AD PRS+ APOE4+

22

100

3.09 (1.68–5.70)

<0.001

12

100

1.32 (0.64–2.72)

0.46

AD PRS− Aβ PRS−

29

390

Ref.

 

32

390

Ref.

 

AD PRS+ Aβ PRS−

8

47

2.22 (0.93–5.26)

0.09

9

47

2.36 (1.01–5.52)

<.05

AD PRS− Aβ PRS+

5

47

1.39 (0.50–3.83)

0.61

5

47

1.19 (0.43–3.32)

0.73

AD PRS+ Aβ PRS+

17

97

2.47 (1.28–4.74)

<0.01

8

97

0.94 (0.41–2.15)

0.87

  1. Model covariates included age, sex, education, and 10 principal components.
  2. Bolded results indicate statistical significance, p < 0 .05.
  3. *Additionally adjusted for APOE status.
  4. AD Alzheimer’s disease, APOE4+ apolipoprotein E ≥ 1 ε4 allele, ND participants without dementia diagnosis, PRS genetic risk score, SD standard deviation, VD vascular dementia.
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