Fig. 6: Overexpression of BRUCE rescues axons in HT22 cells. The HT22 cells were treated with both mimic-NC and o-NC, both miR-204 mimic and oe-NC, and both miR-204 mimic and oe-BRUCE. | Translational Psychiatry

Fig. 6: Overexpression of BRUCE rescues axons in HT22 cells. The HT22 cells were treated with both mimic-NC and o-NC, both miR-204 mimic and oe-NC, and both miR-204 mimic and oe-BRUCE.

From: BRUCE silencing leads to axonal dystrophy by repressing autophagosome-lysosome fusion in Alzheimer’s disease

Fig. 6

A The miR-204 expression and mRNA expression of BRUCE in cells detected by RT-qPCR. B The protein expression of BRUCE in cells detected by Western blot analysis. C The fusion of autophagosome and lysosome in cells detected by immunofluorescence staining (400×). D The immunofluorescence staining of axons in HT22 cells detected by immunofluorescence staining. *p < 0.05 compared with cells treated with both mimic-NC ad oe-NC; #p < 0.05 compared with cells treated with both miR-204 mimic and oe-NC. The experiment was repeated three times independently.

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