Fig. 7: The regulatory mechanism involving miR-204/BRUCE/STX17/BDNF that affects the dystrophic axons induced by AD via autophagosome–lysosome fusion mediation.

Silencing of miR-204 promoted BRUCE to enhance the STX17-mediated autophagosome-lysosome fusion, thus improving the BDNF nuclear transport and alleviating the dystrophic axons of AD mice.