Fig. 2: Representation of the imbalance between 5-HT2AR conformations towards the state preferentially labelled by agonists observed in the prefrontal cortex of subjects with schizophrenia. | Translational Psychiatry

Fig. 2: Representation of the imbalance between 5-HT2AR conformations towards the state preferentially labelled by agonists observed in the prefrontal cortex of subjects with schizophrenia.

From: Opposite alterations of 5­HT2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile

Fig. 2

The disequilibrium promotes a G-protein overactivation in response to 5-HT2AR agonists20. Based on this hypothesis, agonist radioligands should identify higher binding sites and inverse agonist radioligands should label lower binding sites in schizophrenia than in controls. Antagonist radioligands would not discriminate between schizophrenia and control subjects.

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