Fig. 3: Alterations of 5-HT_2A receptor density in schizophrenia.

Saturation curves of the specific [¹⁸F]altanserin (A), [³H]LSD (B) and [³H]MDL100907 (C) binding to membranes of post-mortem frontal cortex from subjects with schizophrenia and presence of antipsychotic drugs in the blood at the time of death (antipsychotic-treated), subjects with schizophrenia and no antipsychotic drugs in the blood (antipsychotic-free), and matched control subjects. Each schizophrenia group was analysed vs. the respective control group, but in order to clarify, here the two control groups are shown together. The curves represent the best-fit estimation generated by the non-linear co-analysis of individual results in each group. The density of 5-HT_2ARs is expressed as the asymptote value (B_max) of the radioligand bound. The affinity of the radioligand is expressed by the concentration of radioligand that promotes the half-maximal bound (K_d). Points representing means were not used for statistical analysis.