Fig. 5: Comparison of probability of loss-of-function intolerance (pLI), probability of mutation, and haploid insufficiency of Neuronal Essential Genes (NEGs) and Achilles Project-specific essential genes (ACEGs).

a pLI of NEGs and ACEGs. b Probability of mutation of NEGs and ACEGs. c Haploid insufficiency rate of NEGs and ACEGs. d Transcript Length of NEGs and ACEGs. e Tissue expression specificities of NEGs and ACEGs.