Fig. 3: Relationship between change in regional translocator protein total distribution volume and change in hamilton depression rating scale scores. | Translational Psychiatry

Fig. 3: Relationship between change in regional translocator protein total distribution volume and change in hamilton depression rating scale scores.

From: A double-blind placebo-controlled trial of minocycline on translocator protein distribution volume in treatment-resistant major depressive disorder

Fig. 3

There were no significant relationships between the change in prefrontal cortex, anterior cingulate cortex, or insula TSPO VT with change in HDRS scores (repeated measures ANOVA, TSPO VT as dependent variable, effect of HDRS change as covariate, F1,19 = 0.66–0.06, P = 0.43–0.82). Similarly, nonsignificant effects were observed within the minocycline treated group alone. ACC anterior cingulate cortex, HAB high-affinity binder, HDRS Hamilton Depression Rating Scale, MAB mixed-affinity binder, PFC prefrontal cortex, TSPO VT translocator protein total distribution volume.

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